22 December 2005
Differential neuronal expression of manganese superoxide dismutase in Alzheimer'sDisease.
David L. Marcus, James A. Strafaci, Michael L. FreedmanMed Sci Monit 2006; 12(1): BR8-14 :: ID: 443169
Abstract
Background: Manganese-dependent superoxide dismutase (MnSOD) is a majordefense mechanism against potential cellular damage by reactive oxygen species (ROS). We have reportedincreased lipid peroxidation and decreased Cu/Zn SOD enzymatic activity in the temporal cortex of Alzheimer'sdiseased (AD) brains. Material/Methods: We now report the expression of MnSOD in the hippocampus of AD(n=8) and non-AD patients (n=7) via immunohistochemical methods, in both neuronal and non neuronal cells.We tested the hypothesis that there is differential expression of MnSOD in the CA1, CA2/3, and CA4 regionof the hippocampus which may account for the neuronal loss seen in Alzheimer's disease. For neuronalcells, profile counts were made and expressed as positive neuronal profiles (MnSOD-IR) per mm(2) withinhippocampal regions CA1, CA2/3, and CA4. Results: The AD MnSOD-IR counts were over 9-fold higher in theCA2/3 region (p
Keywords: Alzheimer Disease - enzymology, Aged, 80 and over, Free Radicals - metabolism, Hippocampus - enzymology, Neurons - enzymology, Regression Analysis, Superoxide Dismutase - metabolism
737 12
Editorial
01 November 2023 : Editorial
Editorial: Factors Driving New Variants of SARS-CoV-2, Immune Escape, and Resistance to Antiviral Treatments as the End of the COVID-19 Pandemic is DeclaredDOI: 10.12659/MSM.942960
Med Sci Monit 2023; 29:e942960
In Press
28 Nov 2023 : Clinical Research
Impact of Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography on Therapeutic Decisions and ...Med Sci Monit In Press; DOI: 10.12659/MSM.942122
28 Nov 2023 : Clinical Research
Long-Term Outcomes of Decompression and Grafting in Acute Pathological Proximal Femur Fractures in Children...Med Sci Monit In Press; DOI: 10.12659/MSM.943031
27 Nov 2023 : Clinical Research
Comparison of Outcomes from Emergency Admissions to a Major Trauma Center in Turkey of 1646 Elderly Patient...Med Sci Monit In Press; DOI: 10.12659/MSM.942916
27 Nov 2023 : Clinical Research
Evaluating Modified Ultrasound-Guided Serratus Anterior Plane Block for Enhanced Postoperative Recovery in ...Med Sci Monit In Press; DOI: 10.12659/MSM.942757
Most Viewed Current Articles
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292