Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

22 December 2005

Association between oxygen consumption and nitric oxide production during therelaxation response.

Jeffery A. Dusek, Bei-Hung Chang, Jamil Zaki, Sara W. Lazar, Sara Lazar, George B. Stefano, Ann L. Wohlhueter, Patricia L. Hibberd, Herbert Benson

Med Sci Monit 2006; 12(1): CR1-10 :: ID: 443179

Abstract

Background: Mind/body practices that elicit the relaxation response (RR)are currently practiced by over 30% of American adults. RR elicitation reduces volumetric oxygen consumption(VO[sub]2[/sub]) from rest and counteracts the effects of stress, although the mechanisms mediating the RR remainunknown. This study was designed to investigate whether RR elicitation is mediated by nitric oxide (NO).We developed a method to quantify depth of RR using change in VO[sub]2[/sub] (slope) during RR elicitation. Weevaluated whether depth of RR elicitation was correlated with changes in NO, as measured by percentagechanges in fractional exhaled nitric oxide (F[sub]E[/sub]NO). Material/Methods: We conducted a randomized, controlledtrial, in which 46 subjects were randomized to either 8-weeks of RR training using audiotapes (n=34)or 8-weeks of exposure to a control condition - receiving health-education by audiotapes (n=12). Priorto randomization, VO[sub]2[/sub]and F[sub]E[/sub]NO were measured while subjects listened to a control audiotape. Eightweeks later, VO[sub]2[/sub]and F[sub]E[/sub]NO were measured while the RR group listened to a RR-eliciting audiotape andthe control group listened to a control audiotape. Results: Prior to receiving any training, there wasno association between VO[sub]2[/sub]slope and F[sub]E[/sub]NO. After training, there was an inverse correlation betweenVO[sub]2[/sub] slope and F[sub]E[/sub]NO in the RR group (r=-0.41, P=0.037, n=26), but not in the control group (r=0.12,P=0.78, n=8). Conclusions: Depth of RR elicitation was associated with increased concentrations of F[sub]E[/sub]NOafter RR training. The RR may be mediated by NO helping to explain its clinical effects in stress-relateddisorders.

Keywords: Nitric Oxide - biosynthesis, Relaxation - physiology, Relaxation Therapy, Statistics as Topic, Tape Recording

Add Comment 0 Comments

Editorial

01 February 2024 : Editorial  

Editorial: Global Health Concerns as Vaccine-Preventable Infections Including SARS-CoV-2 (JN.1), Influenza, Respiratory Syncytial Virus (RSV), and Measles Continue to Rise

Dinah V. Parums

DOI: 10.12659/MSM.943911

Med Sci Monit 2024; 30:e943911

0:00

In Press

08 Jan 2024 : Review article  

Review of Approaches to the Management of Vertical Dental Root Fractures and Tooth Preservation

Med Sci Monit In Press; DOI: 10.12659/MSM.943100  

03 Jan 2024 : Clinical Research  

Comparative Efficacy of Ultrasound-Guided Cervical Fascial Infiltration versus Periarticular Administration...

Med Sci Monit In Press; DOI: 10.12659/MSM.942044  

08 Feb 2024 : Clinical Research  

Predictors of Mortality in Veterans with Amyotrophic Lateral Sclerosis: Respiratory Status and Speech Disor...

Med Sci Monit In Press; DOI: 10.12659/MSM.943288  

19 Feb 2024 : Clinical Research  

Patterns and Outcomes of Traumatic Suicides: A Retrospective Study of 132 Patients Admitted to a Turkish Me...

Med Sci Monit In Press; DOI: 10.12659/MSM.943505  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750