Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 February 2006

Matrix metalloproteinase inhibitor (ONO-4817) attenuates ischemia-reperfusion injury in rat lung

Takehiko Shimoyama, Noriyuki Tabuchi, Jihwa Chung, Takatoshi Koyama, Makoto Sunamori

Med Sci Monit 2006; 12(2): BR51-56 :: ID: 445227


Background: Ischemia-reperfusion injury of the lungs seems to be initiatedby the activation of alveolar macrophages, and mediated by matrix metalloproteinases (MMP)s, althoughtheir roles have not been fully elucidated. Therefore, we used a novel MMP inhibitor (ONO-4817) withhigh affinities for MMP-2 and MMP-9 to investigate the roles of MMPs in reperfusion injury of the lungs.Material/Methods: After 18 h of cold ischemia, isolated rat lungs were ventilated and reperfused. Lungswithout ischemia served as controls. Lungs were reperfused with fresh blood with or without the MMP inhibitorfor 120 min at 37 degrees C. Results: The oxygenation capacity of lungs after ischemia deteriorated progressivelyduring 120 min of reperfusion, but was preserved by the MMP inhibitor (p

Keywords: Antigens, CD11c - metabolism, Antigens, CD31 - metabolism, Lung - physiopathology, Lung Injury, Macrophages, Alveolar - pathology, Matrix Metalloproteinase Inhibitors, Neutrophils - pathology, Phenyl Ethers - pharmacology, Protease Inhibitors - pharmacology, Reactive Oxygen Species - metabolism, Reperfusion Injury - prevention & control

Add Comment 0 Comments

561 5


01 May 2023 : Editorial  

Editorial: Twenty Years On from Sequencing the Human Genome, Personalized/Precision Oncology Prepares to Meet the Challenges of Checkpoint Inhibitor Therapy

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.940911

Med Sci Monit 2023; 29:e940911


In Press

31 May 2023 : Review article  

Prevalence, Diagnosis, and Management of Eclampsia and the Need for Improved Maternal Care: A Review

Med Sci Monit In Press; DOI: 10.12659/MSM.939919  

30 May 2023 : Clinical Research  

A Case-Control Study of Cognitive Function in Patients with End-Stage Renal Disease Before and After Hemodi...

Med Sci Monit In Press; DOI: 10.12659/MSM.940409  

30 May 2023 : Review article  

A Review of the Role of the Zebrafish (Danio reiro) in Preclinical and Clinical Models of Biomarker Identif...

Med Sci Monit In Press; DOI: 10.12659/MSM.940550  

30 May 2023 : Database Analysis  

The COVID-19 Crisis and the Incidence of Alcohol-Related Deaths in Poland

Med Sci Monit In Press; DOI: 10.12659/MSM.940904  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788


30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750