Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 February 2006

Bifenthrin inhibits neurite outgrowth in differentiating PC12 cells.

Van Tran, Natalie Hoffman, Adaobi Mofunanaya, Stephen Pryor, Olutosin Ojugbele, Ashlea McLaughlin, Lydia Gibson, Josephine A. Bonventre, Katherine Flynn, Benjamin Weeks

Med Sci Monit 2006; 12(2): BR57-62 :: ID: 445228


Background: Bifenthrin is a third generation member of the synthetic pyrethroidfamily of insecticides. As a new pesticide within a relatively new class of pesticides, bifenthrin isconsidered relatively safe. Here, we used the PC12 neuronal cell line to examine the effect of bifenthrinon the formation of neurites and the potential developmental neurotoxicity of this pesticide. Material/Methods:PC12 cells were exposed to varying concentrations of technical grade bifenthrin or Ortho Home Defense[sup]®[/sup].Cell viability was determined using the AlmarBlue Toxicity Assay. Nontoxic concentrations of these chemicalswere concomitantly with nerve growth factor and neurite outgrowth was assessed. Results: Ortho Home Defense[sup]®[/sup]preparation reduced PC12 cell viability by approximately 50% and 70% at dilutions that correlate to bifenthrinconcentrations of 10[sup]-5[/sup] M and 10[sup]®[/sup] M, respectively. In contrast, technical grade bifenthrin, was nottoxic to PC12 cells at 10[sup]-3[/sup] M, which was the highest concentration tested that was soluble. At "nontoxic"concentrations of 10[sup]-7[/sup] M and 10[sup]-6[/sup] M, the Ortho Home Defense[sup]®[/sup] inhibited nerve growth factor-mediatedneurite outgrowth by 30% and 55% respectively. Furthermore the nontoxic concentrations of technical gradebifenthrin of 10[sup]-6[/sup] M and 10[sup]-3[/sup] M inhibited neurite outgrowth by approximately 35% and 75% respectively.Conclusions: These data suggest that the toxicity of the Ortho Home Defense[sup]®[/sup] preparation was dueto the "inert" additives in the preparation and not the bifenthrin itself. Further, these data suggestthat, even in the absence of overt toxicity, bifenthrin may have deleterious effects to developing nervoussystem.

Keywords: Cell Differentiation, Cell Survival - drug effects, Insecticides - toxicity, Neurites - pathology, Neurotoxins - toxicity, Pyrethrins - toxicity



01 January 2023 : Editorial  

Editorial: Current Status of Two Adjuvanted Malaria Vaccines and the World Health Organization (WHO) Strategy to Eradicate Malaria by 2030

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.939357

Med Sci Monit 2023; 29:e939357


26 January 2023 : Editorial  

Editorial: The XBB.1.5 (‘Kraken’) Subvariant of Omicron SARS-CoV-2 and its Rapid Global Spread

Med Sci Monit In Press; DOI: 10.12659/MSM.939580  

19 January 2023 : Clinical Research  

Evaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...

Med Sci Monit In Press; DOI: 10.12659/MSM.938892  

27 December 2022 : Clinical Research  

Effect of Physiotherapy to Correct Rounded Shoulder Posture in 30 Patients During the COVID-19 Pandemic in ...

Med Sci Monit 2022; 28:e938926

In Press

27 Jan 2023 : Database Analysis  

Association Between Neutrophil-Lymphocyte Ratio and All-Cause Mortality in Critically Ill Patients with Chr...

Med Sci Monit In Press; DOI: 10.12659/MSM.938554  

27 Jan 2023 : Clinical Research  

Proposal for a Simple Equation for Limb Muscle Weight Calculation

Med Sci Monit In Press; DOI: 10.12659/MSM.938606  

26 Jan 2023 : Editorial  

Editorial: The XBB.1.5 (‘Kraken’) Subvariant of Omicron SARS-CoV-2 and its Rapid Global Spread

Med Sci Monit In Press; DOI: 10.12659/MSM.939580  

20 Jan 2023 : Clinical Research  

A Study of 42 Partially Edentulous Patients with Single-Crown Restorations and Implants to Compare Bone Los...

Med Sci Monit In Press; DOI: 10.12659/MSM.939225  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750