Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 February 2006

Outpatient tinzaparin therapy in pulmonary embolism quantified with ventilation/perfusion scintigraphy

Carl-Gustav Olsson, Carl-Gustav Olsson, Berit Olsson, Pernilla Magnusson, Pernilla Magnusson, Margareta S Carlsson, Marika Bajc

Med Sci Monit 2006; 12(2): PI9-13 :: ID: 445251


Background: Out-of-hospital treatment of patients with deep-vein thrombosis(DVT) is routine in many countries regardless of frequent concomitant asymptomatic pulmonary embolism(PE) in this group. However, patients with symptoms and verified PE are still regularly treated in hospital.The objectives were to test a model for outpatient tinzaparin therapy and to evaluate its safety andefficacy in patients with symptomatic, small or medium-sized PE using quantitative ventilation/perfusionscintigraphy (qV/P SCINT) for patient selection and follow up. Material/Methods: This prospective studyincluded 102 patients treated with tinzaparin and warfarin for 5 days at a patient hotel. PE was quantifiedscintigraphically as loss of perfusion with preserved ventilation at segmental or subsegmental levels(mismatch). Points were attributed to segments of reduced ventilation (RoVent) and perfusion (RoPer).A holistic principle of interpretation was applied. Patients were excluded if they had >14 RoPer points(7 segments) or >7 RoVent points. Clinical follow-up and scintigraphy were repeated at discharge in 100patients and after 13 months on average. Results: Embolism diminished by 44% after 5 days and demandingsymptoms declined. There was no thromboembolic mortality in the trial. At late follow-up, PE had notrecurred in patients with resolution after 5 days. In those with insufficient early response, persistentperfusion defects were usually observed. Conclusions: The results indicate the safety and efficacy ofoutpatient treatment of PE according to our model and merit larger, multicenter, controlled studies.

Keywords: Ambulatory Care, Fibrinolytic Agents - therapeutic use, Heparin, Low-Molecular-Weight - therapeutic use, Prospective Studies, Pulmonary Embolism - radionuclide imaging, Radiopharmaceuticals - diagnostic use, Technetium Tc 99m Pentetate - diagnostic use, Ventilation-Perfusion Ratio

Add Comment 0 Comments


01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204


In Press

15 Jan 2024 : Clinical Research  

Comparison of Modified Shock Index and Shock Index for Predicting Massive Transfusion in Women with Primary...

Med Sci Monit In Press; DOI: 10.12659/MSM.943286  


15 Jan 2024 : Database Analysis  

Bibliometric Analysis of Brain Stimulation Technologies in Sleep Disorders

Med Sci Monit In Press; DOI: 10.12659/MSM.942687  

15 Jan 2024 : Clinical Research  

Clinical Outcomes of Arthroscopic Surgery in Patients with Gluteal Muscle Contracture: Single-Institution R...

Med Sci Monit In Press; DOI: 10.12659/MSM.942945  

17 Jan 2024 : Laboratory Research  

Impact of Auxiliary Features on Retention of Short Dental Crowns: An In-Vitro Analysis of Box and Groove Pr...

Med Sci Monit In Press; DOI: 10.12659/MSM.943401  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387


17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799


14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750