The evaluation of lipid and lipoprotein profiles in liver diseases hasimportant cognitive aspects and provides practical information contributing to the diagnosis of liverpathology. There are few studies of this problem using the ultracentrifugation method. AIM OF THE STUDY:A comparison of lipid profile (obtained by plasma ultracentrifugation) in patients with primary biliarycirrhosis (PBC) and chronic hepatitis (CH). MATERIAL AND METHODS: 103 percutaneous liver biopsies wereroutinely performed from 1994 to 1997. Blood samples were taken from all the patients at the time ofbiopsy for further evaluation of lipid profile. 15 patients with PBC and 15 patients with CH (of HBVor/and HCV etiology) were studied. RESULTS: In patients with CH mean total, esterified and free cholesterollevels (166 mg%, 117.6 mg% and 48.1 mg%, respectively) were significantly lower (p < 0.002; p < 0.004;p < 0.006, respectively) than in patients with PBC (237.5 mg%, 165.7 mg% and 71.8 mg%, respectively).The phospholipid concentration in sera of patients with PBC were significantly higher (271.1 mg%, p

Keywords: Ultracentrifugation