Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

10 April 2006

Grape Seed Proanthocyanidin Extract (GSPE) and antioxidant defense in the brain of adult rats.

Asha Devi, Adiayara Bosse Jolitha, Naokata Ishii

Med Sci Monit 2006; 12(4): BR124-129 :: ID: 448893

Abstract

Background: Proanthocyanidin (PA) is a naturally occurring antioxidantfrom grape seed extract. The present study aims at assessing the neuroprotective effects of grape seedproanthocyanidin (GSPE) on the cerebral cortex (CC), cerebellum (CB), and hippocampus (HC) in the adultrat brain. Material/Methods: GSPE was orally administered at 25, 50, and 75 mg per kg body weight dailyand for a total period of 9 weeks. Antioxidant enzymes (AOEs), superoxide dismutase (SOD), and catalase(CAT) were analyzed along with malondialdehyde (MDA) and protein carbonyl content (PCC) as markers oflipid peroxidation (LPO) and protein oxidation (PO). The cholinergic system was studied by analyzingcholine acetyl tranferase (ChAT) and acetylcholine esterase (AChE) activites along with acetylcholinecontent (ACh). Results: The results obtained revealed an increased SOD activity in the 75-mg PA-supplementedanimals, with a substantial decrease in MDA and PCC. The cholinergic neurotransmittary system analysisshowed increased ChAT activity indicative of increased Ach content in the supplemented animals and theincrease was more in the 75-mg PA group with a concomitant and moderate decrease in AChE activity. Regionalchanges were more with reference to HC. Conclusions: Our study shows that PA intake in moderately lowquantity is effective in up-regulating the antioxidant defense mechanism by attenuating LPO and PO. Changesin the cholinergic system, however, indicate an increase in the ACh concentration with a moderate reductionin AChE activity, suggesting further that PA may have a potent role in enhancing cognition in older rats.

Keywords: Vitis - chemistry, Superoxide Dismutase - metabolism, Seeds - chemistry, Rats, Wistar, Protein Carbonylation - drug effects, Proanthocyanidins - pharmacology, Malondialdehyde - metabolism, Lipid Peroxidation - drug effects, Choline O-Acetyltransferase - metabolism, Catalase - metabolism, Brain - metabolism, Antioxidants - pharmacology, Acetylcholine - metabolism, Acetylcholinesterase - metabolism

Add Comment 0 Comments

Editorial

01 May 2024 : Editorial  

Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)

Dinah V. Parums

DOI: 10.12659/MSM.944927

Med Sci Monit 2024; 30:e944927

In Press

Database Analysis  

Long-Term Prognosis of Patients Undergoing Percutaneous Coronary Intervention: The Impact of Serum Creatini...

Med Sci Monit In Press; DOI: 10.12659/MSM.943063  

Database Analysis  

Maternal Exposure to Environmental Air Pollution and Premature Rupture of Membranes: Evidence from Southern...

Med Sci Monit In Press; DOI: 10.12659/MSM.943601  

Animal Research  

Enhanced Bone Healing Through Systemic Capsaicin Administration: An Experimental Study on Wistar Rats

Med Sci Monit In Press; DOI: 10.12659/MSM.942485  

Clinical Research  

Differential Inflammatory Responses in Adult and Pediatric COVID-19 Patients: Implications for Long-Term Co...

Med Sci Monit In Press; DOI: 10.12659/MSM.944052  

Most Viewed Current Articles

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750