Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

10 April 2006

Physiologic microcirculation of the heterotopically transplanted rat liver with portal vein arterialization depending on optimal stent diameter.

Karina Schleimer, Dirk L. Stippel, Hans-U Kasper, Christian Suer, Samir Tawadros, Samir Tawadros, K.Tobias E. Beckurts

Med Sci Monit 2006; 12(4): BR140-145 :: ID: 448895

Abstract

Background: Clinical experience with portal vein arterialization (PVA)in liver transplantation is controversial. One reason for this is the lack of standardized flow regulation.The present experiments aimed to establish flow regulation in the arterialized portal vein for heterotopicauxiliary liver transplantation (HALT), to obtain physiological portal blood flow, and to compare thistechnique with orthotopic liver transplantation. Material/Methods: Lewis rats were divided into 7 groups(n=8 transplantations/group). Group: A I-IV: In HALT, the portal vein was anastomosed to the right renalartery using stents with different diameters (0.2, 0.3, 0.4, 0.5 mm). Afterwards, HALT with PVA usingthe stent diameter that had achieved the most physiological portal blood flow (group B II) was comparedwith orthotopic liver transplantation with porto-portal anastomosis (group B III) and to the sham group(B I). Results: After reperfusion, only the 0.3 mm stent resulted in an average blood flow in the arterializedportal vein in HALT which was within the normal range (1.7+/-0.4 ml/min/g liver weight). The parametersof microcirculation and early graft function were significantly better in group B II than in group BIII (functional sinusoidal density: 335+/-48 vs. 224+/-31/cm, diameter of sinusoids: 6.4+/-0.6 vs. 5.2+/-0.6microm, diameter of postsinusoidal venules: 31.1+/-3.3 vs. 25.5+/-2.0 microm, bile-production: 27+/-8vs. 19+/-5 microl/h/g liver weight). Conclusions: Using an optimal stent diameter in HALT with portalvein arterialization, an adequate flow-regulation can be achieved. Avoiding portal hyper- and hypoperfusion,good results for microcirculation and early graft function can be obtained.

Keywords: Arteriovenous Shunt, Surgical, Liver Circulation - physiology, Liver Transplantation - physiology, Microcirculation - physiology, Portal Vein - surgery, Rats, Inbred Lew, Stents, Transplantation, Heterotopic - physiology, Transplantation, Isogeneic

Add Comment 0 Comments

Editorial

01 April 2024 : Editorial  

Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug Resistance

Dinah V. Parums

DOI: 10.12659/MSM.944600

Med Sci Monit 2024; 30:e944600

0:00

In Press

04 Mar 2024 : Clinical Research  

Injury-Admission Time is an Independent Risk Factor for Deep Vein Thrombosis in Older Patients with Osteopo...

Med Sci Monit In Press; DOI: 10.12659/MSM.943587  

0:00

04 Mar 2024 : Clinical Research  

Evaluation of the Interrater Reliability of Sonographic Measurements of Muscle Thickness of 38 Piriformis M...

Med Sci Monit In Press; DOI: 10.12659/MSM.943720  

0:00

05 Apr 2024 : Clinical Research  

Comparative Analysis of Transoral Endoscopic Parathyroidectomy Vestibular Approach and Focused Open Surgery...

Med Sci Monit In Press; DOI: 10.12659/MSM.944128  

05 Mar 2024 : Clinical Research  

Muscular Function Recovery from General Anesthesia in 132 Patients Undergoing Surgery with Acceleromyograph...

Med Sci Monit In Press; DOI: 10.12659/MSM.942780  

Most Viewed Current Articles

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750