Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

10 April 2006

The presentation and organization of adaptive cytoprotection in the rat stomach,duodenum, and colon.

Stjepan Mise, Ante Tonkic, Valdi Pesutic, Marija Tonkic, Sandro Mise, Vesna Capkun, Lovorka Batelja, Alenka Boban Blagaic, Neven Kokic, Ivan Zoricic, Davor Saifert, Tomislav Anic, Sven Seiwerth, Predrag Sikiric

Med Sci Monit 2006; 12(4): BR146-153 :: ID: 448896


Background: Adaptive cytoprotection could be demonstrated in lesion attenuationwithin the whole gastrointestinal tract, in particular sequences, with onset and duration longer thanthe initial short-lasting period (i.e. one hour) defined by Robert in the stomach only. Material/Methods:Adaptive cytoprotection possibly appeared and lesions were attenuated when the stomach, duodenum or colon,in various combinations and sequences, were challenged with initial (mild) and/or final (strong) irritantsover a two-week period. Rats were challenged with the mild or strong irritants 25% or 96% ethanol intragastrically1 ml/rat (stomach) and cysteamine 40 mg or 400 mg/kg subcutaneously (duodenum), or intrarectally (colon).To postulate the prostaglandin relationship known in Robert's cytoprotection and adaptive cytoprotection,indomethacin (1 mg/kg subcutaneously) was given simultaneously with the second challenge. Results: Administeringthe mild and strong irritant protocols within the same part of the gastrointestinal tract, adaptive cytoprotectionpresents in the stomach (1 h to 14 days), duodenum (2 h to 14 days), but not in the colon. With theseprotocols applied to different parts of the gastrointestinal tract, adaptive cytoprotection cross-reactionwas evident in the stomach-duodenum, duodenum-stomach (1 h-14 days and 2 h-14 days), stomach-colon, andduodenum-colon (both 2-24 hours), but not in the colon-stomach or colon-duodenum. This protection wasfully antagonized with indomethacin. Conclusions: As observed for a day and even weeks, stomach-duodenum-colonadaptive cytoprotection is an important new defensive phenomenon.

Keywords: Colon - physiopathology, Adaptation, Physiological, Cysteamine - toxicity, Duodenum - physiopathology, Ethanol - toxicity, Gastric Mucosa - physiopathology, Intestinal Mucosa - physiopathology, Irritants - toxicity, Necrosis, Rats, Wistar



01 July 2022 : Editorial  

Editorial: World Health Organization (WHO) Variants of Concern Lineages Under Monitoring (VOC-LUM) in Response to the Global Spread of Lineages and Sublineages of Omicron, or B.1.1.529, SARS-CoV-2

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.937676

Med Sci Monit 2022; 28:e937676


27 June 2022 : Clinical Research  

Shoulder Injury Related to Vaccine Administration (SIRVA) in 16 Patients Following COVID-19 Vaccination Who...

Med Sci Monit In Press; DOI: 10.12659/MSM.937430  

27 May 2022 : Clinical Research  

Factors Associated with Falls During Hospitalization for Coronavirus Disease 2019 (COVID-19)

Med Sci Monit 2022; 28:e936547

In Press

01 Jul 2022 : Clinical Research  

Does Early-Period Patient Dissatisfaction Turn Into Satisfaction Over Time After Total Knee Replacement?

Med Sci Monit In Press; DOI: 10.12659/MSM.936792  

30 Jun 2022 : Laboratory Research  

Bcl-2 19-kDa Interacting Protein 3 (BNIP3)-Mediated Mitophagy Attenuates Intermittent Hypoxia-Induced Human...

Med Sci Monit In Press; DOI: 10.12659/MSM.936760  

30 Jun 2022 : Clinical Research  

Antioxidant System and Ions Concentrations After Femoral Neck and Resurfacing Hip Arthroplasty

Med Sci Monit In Press; DOI: 10.12659/MSM.936335  

28 Jun 2022 : Meta-Analysis  

Urodynamics in Early Diagnosis of Diabetic Bladder Dysfunction in Women: A Systematic Review and Meta-Analysis

Med Sci Monit In Press; DOI: 10.12659/MSM.937166  

Most Viewed Current Articles

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Nov 2020 : Review article  

Long-Term Respiratory and Neurological Sequelae of COVID-19

DOI :10.12659/MSM.928996

Med Sci Monit 2020; 26:e928996

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750