10 April 2006
The presentation and organization of adaptive cytoprotection in the rat stomach,duodenum, and colon.Stjepan Mise, Ante Tonkic, Valdi Pesutic, Marija Tonkic, Sandro Mise, Vesna Capkun, Lovorka Batelja, Alenka Boban Blagaic, Neven Kokic, Ivan Zoricic, Davor Saifert, Tomislav Anic, Sven Seiwerth, Predrag Sikiric
Med Sci Monit 2006; 12(4): BR146-153 :: ID: 448896
Background: Adaptive cytoprotection could be demonstrated in lesion attenuationwithin the whole gastrointestinal tract, in particular sequences, with onset and duration longer thanthe initial short-lasting period (i.e. one hour) defined by Robert in the stomach only. Material/Methods:Adaptive cytoprotection possibly appeared and lesions were attenuated when the stomach, duodenum or colon,in various combinations and sequences, were challenged with initial (mild) and/or final (strong) irritantsover a two-week period. Rats were challenged with the mild or strong irritants 25% or 96% ethanol intragastrically1 ml/rat (stomach) and cysteamine 40 mg or 400 mg/kg subcutaneously (duodenum), or intrarectally (colon).To postulate the prostaglandin relationship known in Robert's cytoprotection and adaptive cytoprotection,indomethacin (1 mg/kg subcutaneously) was given simultaneously with the second challenge. Results: Administeringthe mild and strong irritant protocols within the same part of the gastrointestinal tract, adaptive cytoprotectionpresents in the stomach (1 h to 14 days), duodenum (2 h to 14 days), but not in the colon. With theseprotocols applied to different parts of the gastrointestinal tract, adaptive cytoprotection cross-reactionwas evident in the stomach-duodenum, duodenum-stomach (1 h-14 days and 2 h-14 days), stomach-colon, andduodenum-colon (both 2-24 hours), but not in the colon-stomach or colon-duodenum. This protection wasfully antagonized with indomethacin. Conclusions: As observed for a day and even weeks, stomach-duodenum-colonadaptive cytoprotection is an important new defensive phenomenon.
Keywords: Colon - physiopathology, Adaptation, Physiological, Cysteamine - toxicity, Duodenum - physiopathology, Ethanol - toxicity, Gastric Mucosa - physiopathology, Intestinal Mucosa - physiopathology, Irritants - toxicity, Necrosis, Rats, Wistar
01 June 2023 : EditorialEditorial: Infectious Disease Surveillance Using Artificial Intelligence (AI) and its Role in Epidemic and Pandemic Preparedness
Med Sci Monit 2023; 29:e941209
08 Jun 2023 : Clinical ResearchRisk Factors for New Vertebral Compression Fracture After Percutaneous Vertebral Augmentation: A Retrospect...
Med Sci Monit In Press; DOI: 10.12659/MSM.940134
08 Jun 2023 : Clinical ResearchA Nomogram for Identifying HR+/Her2- Breast Cancer Patients with Positive Sentinel Lymph Nodes and Omitted ...
Med Sci Monit In Press; DOI: 10.12659/MSM.940124
08 Jun 2023 : Clinical ResearchBurden of COVID-19 on Mental Health of Resident Doctors in Poland
Med Sci Monit In Press; DOI: 10.12659/MSM.940208
08 Jun 2023 : Clinical ResearchRisk Prediction for Rapidly Progressive Interstitial Lung Disease in Anti-MDA5-Positive Dermatomyositis: Th...
Med Sci Monit In Press; DOI: 10.12659/MSM.940251
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : EditorialEditorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...
Med Sci Monit 2022; 28:e935952