10 April 2006
Epistatic effects between two genes in the renin-angiotensin system and systolic blood pressure and coronary artery calcification.Sharon L.R. Kardia, Lawrence F. Bielak, Leslie A. Lange, James M. Cheverud, Eric Boerwinkle, Stephen T. Turner, Patrick F. Sheedy II, Patricia A. Peyser
Med Sci Monit 2006; 12(4): CR150-158 :: ID: 448900
Background: Coronary artery calcification (CAC) is an important indicatorof future coronary artery disease events. Since elevated blood pressure (BP) is an important predictorof CAC, genetic polymorphisms in the renin-angiotensin system and their interaction may play a role inexplaining CAC quantity variation. Material/Methods: As part of the Epidemiology of Coronary Artery CalcificationStudy, 166 asymptomatic women and 166 asymptomatic men were genotyped for the insertion/deletion polymorphismin the angiotensin-converting enzyme (ACE) gene and the -6 promoter polymorphism of the angiotensinogen(AGT) gene. We used a novel method to detect gene-gene interaction and compared it to the standard two-wayanalysis of variance (ANOVA) method. Results: Based on a two-way ANOVA model, there was no evidence forepistasis for either systolic BP or CAC in either men or women. However, using a novel method, we foundevidence of significant gene-gene interaction in systolic BP in men and gene-gene interaction in bothsystolic BP levels and CAC quantity in women. Conclusions: Our study demonstrates that new methods ofassessing epistasis maybe important in understanding the complex genetics of systolic blood pressureas well as subclinical coronary atherosclerosis.
Keywords: Epistasis, Genetic, Renin-Angiotensin System - genetics, Promoter Regions, Genetic, Polymorphism, Genetic, Peptidyl-Dipeptidase A - genetics, Genotype, Aged, 80 and over, DNA - genetics, Coronary Vessels - pathology, Coronary Artery Disease - genetics, Calcinosis - genetics, Blood Pressure - genetics, Base Sequence, Angiotensinogen - genetics
01 August 2022 : EditorialEditorial: Long-Term Effects of Symptomatic and Asymptomatic SARS-CoV-2 Infection in Children and the Changing Pathogenesis of Common Childhood Viruses Driven by the COVID-19 Pandemic
Med Sci Monit 2022; 28:e937927
08 Aug 2022 : Clinical ResearchA 3-Year Clinical Evaluation of Endodontically Treated Posterior Teeth Restored with Resin Nanoceramic Comp...
Med Sci Monit In Press; DOI: 10.12659/MSM.937331
08 Aug 2022 : Clinical ResearchHemoglobin/Red Blood Cell Distribution Width Ratio in Peripheral Blood Is Positively Associated with Progno...
Med Sci Monit In Press; DOI: 10.12659/MSM.937146
05 Aug 2022 : Clinical ResearchA Retrospective Study of 98 Elderly Patients with High-Risk Lateral Femoral Wall Intertrochanteric Hip Frac...
Med Sci Monit In Press; DOI: 10.12659/MSM.936923
Most Viewed Current Articles
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292