Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 July 2006

Outcome and prognosis of severe thrombotic microangiopathies treated by plasmaexchange.

Laure Federici, Kada Klouche, Laurent Amigues, Tarik Kanouni, Ernesto Lopez-Martinez, Pascal Latry, Jean Jacques Beraud, Jean Francois Rossi

Med Sci Monit 2006; 12(7): CR302-307 :: ID: 452202


Background: Plasma exchange (PE) therapy has dramatically improved theoutcome of thrombotic microangiopathies (TMA) in adults. However, resistance to PE, which indicates apoor prognosis, is observed in 1/3 of patients and remains not fully understood. We evaluated in thisstudy the survival and the long-term outcome of severe TMA treated by PE and identified the predictivefactors of resistance to PE and of mortality. Material/Methods: Records of adults with severe TMA treatedby PE were reviewed. Clinical and biological data, therapeutic delay to PE, plasma volume exchange perprocedure, and number of PE sessions were collected. Mortality was assessed at one month and at one-yearfollow-up. All data were analyzed and compared between survived/deceased and between responder/non-responderpatients. Results: Nineteen females and six males were included. Mean age (+/-SD) was 46.8+/-16.3 years,Glasgow coma score 11+/-3, and Sequential Organ Failure Assessment (SOFA) score 5.8+/-2.8. Nineteen patientspartially or fully responded to PE. Twenty patients were alive at one month and 19 at one year. The responseto PE was the single discriminating parameter between survivors and non-survivors. A longer delay ofPE and a neoplastic cause of TMA were significantly higher in the non-responders. Conclusions: SevereTMA treated by PE had a fair prognosis, with a survival rate at 76% after one year of follow-up. Unresponsivenessto PE was the only predictive factor of mortality; a neoplastic etiology of TMA and a longer therapeuticdelay of PE were predictive of resistance to PE.

Keywords: Plasma Exchange, Prognosis, Thrombosis - therapy, Vascular Diseases - therapy



01 March 2023 : Editorial  

Editorial: Global Surveillance of Highly Pathogenic Avian Influenza Viruses in Poultry, Wild Birds, and Mammals to Prevent a Human Influenza Pandemic

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.939968

Med Sci Monit 2023; 29:e939968


In Press

28 Mar 2023 : Laboratory Research  

Effects of the Dibenzofuran, Usnic Acid, on Inhibition of Ocular Biofilm Formation Due to Coagulase-Negativ...

Med Sci Monit In Press; DOI: 10.12659/MSM.940266  

28 Mar 2023 : Clinical Research  

Tri-Lock Bone Preservation Stem Versus Conventional Corail Stem in Primary Total Hip Arthroplasty via Direc...

Med Sci Monit In Press; DOI: 10.12659/MSM.939635  

27 Mar 2023 : Database Analysis  

Relationship Between Physical Activity and Adult Asthma Control Using NHANES 2011-2020 Data

Med Sci Monit In Press; DOI: 10.12659/MSM.939350  

27 Mar 2023 : Clinical Research  

Evaluation of the One-Hour ¹³C-Propionate Breath Test in 49 Patients from a Single Center in Japan to Detec...

Med Sci Monit In Press; DOI: 10.12659/MSM.940238  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750