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01 October 2006

Innate anti-viral immunity is associated with the protection elicited by the Simian Immunodeficiency Virus (SIV) live attenuated virus vaccine in cynomolgus monkeys

Delia Goletti, Iole Macchia, Pasqualina Leone, Monica Pace, Leonardo Sernicola, Maria Rosaria Pavone-Cossut, Maria Teresa Maggiorella, Aurelio Cafaro, Barbara Ensoli, Fausto Titti

Med Sci Monit 2006; 12(10): BR330-340 :: ID: 459189

Abstract

Background: The Δ-nef live attenuated virus vaccine approach offered in the SIV-macaque model the opportunity to identify humoral and cell-mediated immune responses associated with protection against viral infections. In addition, soluble factors different from those related to specifi c immune responses appear to correlate with the establishment and maintenance of the protective status.
Material/Methods: Investigated were: 1) the ability of CD8[sup]+

Keywords: Cell-Free System, CD8-Positive T-Lymphocytes - immunology, Gene Products, nef - immunology, Immunity, Innate, Interferon-gamma - biosynthesis, Macaca fascicularis, Simian immunodeficiency virus - physiology, Time Factors, Vaccination, Vaccines, Attenuated - administration & dosage, Viral Vaccines - immunology, Virus Replication - immunology

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750