Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

22 December 2006

Mechanism of gastric emptying through the pyloric sphincter: A human study

Ahmed Shafik, Olfat El Sibai, Ali A. Shafik, Ismail A. Shafi k

Med Sci Monit 2007; 13(1): CR24-29 :: ID: 470145


Background: The current view holds that gastric emptying is effected by the force of the antral peristaltic wave squeezing food particles through pyloric sphincter resistance. Whether this is accomplished by a refl ex action was investigated.
Material/Methods: The study comprised 12 healthy volunteers (age: 42.2±10.6 years). A balloon-tipped and a manometric tube were introduced into the stomach. Pressure responses in the proximal stomach, pyloric antrum, and pyloric sphincter to distension of the proximal stomach and of the antrum were
recorded. Pyloric sphincter distension was induced to test its effect on antral and proximal stomach pressure. These tests were repeated in nine men after separately anesthetizing the pyloric antrum and sphincter.
Results: Distension of the proximal stomach produced no pressure changes in the proximal stomach, pyloric antrum, or sphincter (p>0.05). Antral distension effected a signifi cant rise in antral pressure, but not in the proximal stomach. Signifi cant sphincter pressure decrease occurred only with antral
distension volumes >50 ml. Pyloric sphincter distension produced a signifi cant rise in antral pressure, but not in the proximal stomach. Sphincteric or antral anesthetization produced no pressure changes in the pyloric sphincter, antrum, or proximal stomach.
Conclusions: Pyloric sphincter relaxation upon antral distension implies a refl ex relationship the authors call the “antro-sphincteric inhibitory refl ex”. Pyloric sphincter distension effected antral contraction, which is suggested to be a refl ex in nature and which they term the “sphinctero-antral excitatory refl ex”. It is postulated that these two refl exes act to churn and transport gastric contents to the duodenum.

Keywords: Carbon Dioxide, Anesthesia, Local, Gastric Emptying - physiology, Pressure, Pyloric Antrum - physiology, Pylorus - physiology

Add Comment 0 Comments

631 29


01 June 2023 : Editorial  

Editorial: Infectious Disease Surveillance Using Artificial Intelligence (AI) and its Role in Epidemic and Pandemic Preparedness

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.941209

Med Sci Monit 2023; 29:e941209


In Press

05 Jun 2023 : Clinical Research  

Comparison of Texture and Color Enhancement Imaging with White Light Imaging in 52 Patients with Short-Segm...

Med Sci Monit In Press; DOI: 10.12659/MSM.940249  

05 Jun 2023 : Laboratory Research  

Comparison of Composite Resin (Duo-Shade) Shade Guide with Vita Ceramic Shades Before and After Chemical an...

Med Sci Monit In Press; DOI: 10.12659/MSM.940949  

02 Jun 2023 : Database Analysis  

The COVID-19 Crisis and the Incidence of Alcohol-Related Deaths in Poland

Med Sci Monit In Press; DOI: 10.12659/MSM.940904  

01 Jun 2023 : Clinical Research  

Root Canal Numbers and Configurations in 1080 Permanent Canine Teeth in 270 Saudi Subjects Using Cone-Beam ...

Med Sci Monit In Press; DOI: 10.12659/MSM.940472  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788


30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750