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01 March 2007

The role of heme in hemolysis-induced acute pancreatitis

Murat Saruç, Hakan Yuceyar, Nurten Turkel, Omer Ozutemiz, Isil Tuzcuoglu, Semin Ayhan, Gul Yuce, Isil Coker, Afik Huseyinov

Med Sci Monit 2007; 13(3): BR67-72 :: ID: 475508

Abstract

Background: The aim was to reveal the mechanism of hemolysis-induced acute pancreatitis and to evaluate the role of heme and heme oxygenase activity in inducing pancreatic infl ammation in an experimental
hemolysis model.
Material/Methods: Hemolytic anemia was induced in rats by intraperitoneal injection of 60 mg/kg acetylphenylhydrazine (APH). To evaluate the toxic effect of free heme after hemolysis, heme oxygenase inhibitor
(HOI) was used to inhibit the enzyme which decreases the free heme concentration after hemolysis. One hundred and fi fty rats were divided into two treatment and three control groups. Rats in the hemolysis group were given APH intraperitoneally. Rats in the HOI+hemolysis group were
given Cr(III)mesoporphyrin IX chloride as HOI and then APH intraperitoneally. Serum amylase and lipase levels as well as pancreatic tissue cytokine content were determined and histological examination performed.
Results: No hemolysis or pancreatitis was seen in the control groups. Massive hemolysis was seen in 22 of the 30 rats of the hemolysis group and 20 of the 30 rats of the HOI+hemolysis group. The total pancreatitis rates were 60% and 76.6% in the hemolysis and HOI+hemolysis groups, respectively (p

Keywords: Cytokines - metabolism, Heme - metabolism, Hemolysis, Necrosis, Pancreatitis - pathology, Rats, Wistar

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750