Patterns of free and esterified sterol fractions of the cerebral white matterin severe and moderate experimental hypoxiaJ Dorszewska, Z Adamczewska-Goncerzewicz
Med Sci Monit 2000; 6(2): BR227-231 :: ID: 476616
Cerebral sterols were examined in Wistar strain rats, subjected 4 h, 24h, 14 days or 2 months earlier to severe (2% oxygen) and moderate (7% oxygen) experimental hypoxia. Frombrains of the experimental animals myelin was isolated and examined by gas chromatography coupled withmass spectrometry (GC-MS) to separate and to identify free and esterified (following hydrolysis) cerebralsterols. In both types of hypoxia, the same compounds were identified in fractions of free and esterifiedsterols. Slight differences in sterol content were noted between the two experimental models, involvingcholesterol, the main sterol of the myelin sheath, its smaller sterol precursors (desmosterol, lanosterol)and the less abundant sterols (beta-sitosterol, 24-ethyl-4-cholesten-3-on, cholesta-3,5-dien, cholest-4-en-3-on,22-propyl-3 beta-hydroxy-5,24-cholestadien). Both types (severe and moderate) of hypoxia were found toinduce similar alterations in patterns of cerebral sterols 24 h, 14 days and 2 months following the exposure.Quantitative differences in the sterol pattern were detected only at the very early stage (4 h) of theexperiment.
Keywords: Membrane Lipids - chemistry, Sterols - chemistry, Sterols - metabolism
01 May 2023 : EditorialEditorial: Twenty Years On from Sequencing the Human Genome, Personalized/Precision Oncology Prepares to Meet the Challenges of Checkpoint Inhibitor Therapy
Med Sci Monit 2023; 29:e940911
31 May 2023 : Review articlePrevalence, Diagnosis, and Management of Eclampsia and the Need for Improved Maternal Care: A Review
Med Sci Monit In Press; DOI: 10.12659/MSM.939919
30 May 2023 : Clinical ResearchA Case-Control Study of Cognitive Function in Patients with End-Stage Renal Disease Before and After Hemodi...
Med Sci Monit In Press; DOI: 10.12659/MSM.940409
30 May 2023 : Review articleA Review of the Role of the Zebrafish (Danio reiro) in Preclinical and Clinical Models of Biomarker Identif...
Med Sci Monit In Press; DOI: 10.12659/MSM.940550
30 May 2023 : Database AnalysisThe COVID-19 Crisis and the Incidence of Alcohol-Related Deaths in Poland
Med Sci Monit In Press; DOI: 10.12659/MSM.940904
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : EditorialEditorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...
Med Sci Monit 2022; 28:e935952