30 March 2007
Epidemiology of renal disease in children in the region of Southern Croatia: A 10-year review of regional renal biopsy databases
Mirna Bazina, Meri Glavina-Durdov, Mira Sćukanec-Špoljar, Antonela Bazina, Katarina Vukojević, Dragan Ljutić, Marijan SaragaMed Sci Monit 2007; 13(4): CR172-176 :: ID: 481098
Abstract
Background:Epidemiological data on some renal diseases in children are available from world national registries of renal biopsies. However, there is no published study of biopsy-proven childhood glomerulonephritis in Croatia. This report is the first review of pathohistological data covering a pediatric population over a 10-year period in the Croatian region of Dalmatia.
Material/Methods:A retrospective study was done on all renal biopsies from 65 children under 18 years of age received by the Clinical Hospital Split between 1995 and 2005. The histopathological findings were reviewed to determine the pattern of biopsy-proven glomerulonephritis. Indications for renal biopsy and clinico-pathological correlations were studied. Data on serum creatinine concentration, 24-h proteinuria, hematuria, clinical diagnosis, pathohistological diagnosis, and post-biopsy complications were collected.
Results:The main indications for biopsy were nephrotic syndrome (41.5%), hematuria with proteinuria (23.1%), and isolated hematuria (12.3%). The most frequent renal diseases in decreasing order were mesangioproliferative glomerulonephritis (27.7%), IgA nephropathy (13.8%), and Henoch-Schönlein nephritis (10.8%). Tubulointerstitial nephritis, focal segmental glomerulosclerosis, and endoproliferative glomerulonephritis each accounted for 6.2%. Alport syndrome, fibrillary glomerulonephritis, and minimal change diseases were each found in 4.6% of cases. Other forms of glomerulonephritis were rarely found.
Conclusions:The present data represent the basis for a future Croatian Registry of Renal Biopsies and are an important contribution to the epidemiology of renal diseases in south-eastern Europe. Three cases of fibrillary glomerulonephritis in children with steroid-dependent nephrotic syndrome, not reported in other countries’ registries, were also found. The importance of ultrastructural analysis of biopsy specimens is emphasized.
Keywords: Adolescent, Biopsy - classification, Child, Child, Preschool, Croatia - epidemiology, Kidney Diseases - pathology, Tissue Banks
Editorial
01 April 2025 : Editorial
Editorial: Rapid Testing for the Avian Influenza A(H5N1) Virus is Urgently Required as Infections in Poultry and Dairy Cows are on the Rise, and so is Transmission to HumansDOI: 10.12659/MSM.949109
Med Sci Monit 2025; 31:e949109
In Press
Clinical Research
Longitudinal Evaluation of Metabolic Benefits of Inactivated COVID-19 Vaccination in Diabetic Patients in T...Med Sci Monit In Press; DOI: 10.12659/MSM.947450
Clinical Research
Impact of Voltage Level on Hospitalization and Mortality in Electrical Injury Cases: A Retrospective Analys...Med Sci Monit In Press; DOI: 10.12659/MSM.947675
Clinical Research
Comparative Study of Plantar Load and Foot Posture Characteristics in Male Elite Squash Players and Non-Ath...Med Sci Monit In Press; DOI: 10.12659/MSM.947828
Clinical Research
Dental Students’ Opinions on Use of Artificial Intelligence: A Survey StudyMed Sci Monit In Press; DOI: 10.12659/MSM.947658
Most Viewed Current Articles
17 Jan 2024 : Review article 8,071,874
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
16 May 2023 : Clinical Research 702,992
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Mar 2024 : Editorial 30,169
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and ...DOI :10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
28 Jan 2024 : Review article 24,060
A Review of IgA Vasculitis (Henoch-Schönlein Purpura) Past, Present, and FutureDOI :10.12659/MSM.943912
Med Sci Monit 2024; 30:e943912