Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

30 March 2007

Platelet activation in subjects with subclinical hypothyroidism

Erkan Coban, Gokhan Yazicioglu, Mustafa Ozdogan

Med Sci Monit 2007; 13(4): CR211-214 :: ID: 481108


Background: Coronary heart disease is the major cause of death in the developed world. Platelet activation and aggregation are central processes in the pathophysiology of coronary heart disease. Mean platelet volume (MPV), a determinant of platelet function, is a newly emerging risk factor for atherothrombosis. The present study was designed to evaluate levels of MPV in subclinical hypothyroidic subjects compared with euthyroidic subjects in a cross-sectional study.
Material and methods: Thirty-six subclinical hypothyroidic subjects and 20 euthyroidic control subjects matched for age, gender, and body mass index were selected.
Results: Metabolic parameters and platelet counts were not different among the study groups (<i>p</i>>0.05). The level of MPV was significantly higher in the subclinical hypothyroidic group than in the euthyroidic group (9.9±0.9 fl vs. 9.2±0.7 fl, <i>p</i><0.001). The anti-TPO levels positively correlated to MPV levels in the subclinical hypothyroidic group (<i>p</i><0.05).
Conclusions: These results suggest that subjects with subclinical hypothyroidism tend to have increased platelet activation. Increased platelet activity could contribute to increasing the risk of atherothrombotic complications in subclinical hypothyroidism.

Keywords: Cross-Sectional Studies, Hypothyroidism - physiopathology, Immunoassay, Platelet Activation - physiology, Platelet Count

Add Comment 0 Comments


01 February 2024 : Editorial  

Editorial: Global Health Concerns as Vaccine-Preventable Infections Including SARS-CoV-2 (JN.1), Influenza, Respiratory Syncytial Virus (RSV), and Measles Continue to Rise

Dinah V. Parums

DOI: 10.12659/MSM.943911

Med Sci Monit 2024; 30:e943911


In Press

28 Dec 2023 : Clinical Research  

Prognostic Assessment of Colorectal Cancer Patients after Laparoscopic Surgery: A Comprehensive Evaluation ...

Med Sci Monit In Press; DOI: 10.12659/MSM.942658  


05 Jan 2024 : Clinical Research  

Effectiveness of Glutamine Oral Care in Reducing Oral Mucositis and Improving Oral Health After Neurosurger...

Med Sci Monit In Press; DOI: 10.12659/MSM.942585  

02 Jan 2024 : Clinical Research  

Urinary Concentration of Renal Biomarkers in Healthy Term Neonates: Gender Differences in GST-pi Excretion

Med Sci Monit In Press; DOI: 10.12659/MSM.942819  

29 Dec 2023 : Clinical Research  

Performance of Subcutaneous Implantable Cardioverter Defibrillator (S-ICD) in Chinese Population with Prima...

Med Sci Monit In Press; DOI: 10.12659/MSM.942747  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387


17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799


14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750