Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

21 November 2002

Reversed circadian rhythms of heart rate variability and morning peak occurrence of sustained ventricular tachyarrhythmias in patients with implanted cardioverter defibrillator.

Roland Fries, Sandra Hein, Jochem König

Med Sci Monit 2002; 8(11): CR751-756 :: ID: 4836


BACKGROUND: It is generally supposed that diurnal fluctuations of heart rate variability (HRV) are associated with diurnal variability of occurrence of sudden cardiac death, usually caused by tachyarrhythmias. To date, however, there have been no data comparing circadian rhythms of HRV and circadian variability of malignant ventricular tachyarrhythmias in the same patients. MATERIAL/METHODS: We studied 20 consecutive recipients of implantable cardioverter defibrillators in long-term follow-up, comparing the circadian rhythms of HRV in patients with and without typical morning peak occurrence of ventricular tachyarrhythmias. RESULTS: The HRV marker of vagus activity (RMSSD and HF power) displayed physiological circadian variability (highest values during sleep time, morning dip) only in patients without morning peak of arrhythmic events, and inverse circadian variability in patients with tachyarrhythmic morning peak. The variations in LF power and LF/HF ratio in both groups were not statistically significant, but with respect to the time interval between midnight and noon again showed inverse diurnal variation in patients with and without morning peak of arrhythmic events. CONCLUSIONS: These data suggest an association between a reversed circadian rhythm of HRV and morning peak frequency of tachyarrhythmic events in patients with ICD. As pronounced adrenergic hyperactivity in heart failure is the probable reason for paradoxically reversed circadian HRV variation, this association supports the hypothesis that the morning peak frequency of cardiovascular events may be interpreted as a sign of cardiovascular overload by the natural change from sleep to activity after awakening.

Keywords: Tachycardia, Ventricular - therapy

Add Comment 0 Comments

941 8


01 November 2023 : Editorial  

Editorial: Factors Driving New Variants of SARS-CoV-2, Immune Escape, and Resistance to Antiviral Treatments as the End of the COVID-19 Pandemic is Declared

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville,

DOI: 10.12659/MSM.942960

Med Sci Monit 2023; 29:e942960


In Press

28 Nov 2023 : Clinical Research  

Impact of Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography on Therapeutic Decisions and ...

Med Sci Monit In Press; DOI: 10.12659/MSM.942122  

28 Nov 2023 : Clinical Research  

Long-Term Outcomes of Decompression and Grafting in Acute Pathological Proximal Femur Fractures in Children...

Med Sci Monit In Press; DOI: 10.12659/MSM.943031  

27 Nov 2023 : Clinical Research  

Comparison of Outcomes from Emergency Admissions to a Major Trauma Center in Turkey of 1646 Elderly Patient...

Med Sci Monit In Press; DOI: 10.12659/MSM.942916  

27 Nov 2023 : Clinical Research  

Evaluating Modified Ultrasound-Guided Serratus Anterior Plane Block for Enhanced Postoperative Recovery in ...

Med Sci Monit In Press; DOI: 10.12659/MSM.942757  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788


30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379


14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750