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01 August 2007

Mean platelet volume in patients with coronary artery ectasia

Nihat Sen, Yusuf Tavil, Hüseyin Ugur Yazici, Fatma Hizal, Sadik Kadri Açikgöz, Adnan Abaci, Atiye Çengel

Med Sci Monit 2007; 13(8): CR356-359 :: ID: 491638

Abstract

Background: Mean platelet volume (MPV) is an indicator of platelet activation, a central process in the pathophysiology of coronary heart disease. The importance of coronary artery ectasia (CAE) lies in the fact that in 85% of cases it is accompanied by atherosclerotic coronary disease. The present study was designed to investigate MPV values in CAE patients in comparison with individuals with normal coronary angiograms.
Material/Methods: MPV was measured in 67 consecutive patients (mean age: 55.3±9.7 years) with isolated CAE and 55 control subjects (mean age: 53.6±10.1 years). Coronary artery ectasia was defined as without any stenotic lesion, on visual assessment, of the coronary arteries with a luminal dilatation 1.5-fold or more of the adjacent normal coronary segments. Four subgroups were composed according to the extension of CAE in coronary arteries.
Results: MPV was significantly higher in patients with CAE than in the control group (9.27±1.32 vs. 8.40±0.95, p<0.001). There were no statistically significant differences in MPV among the subgroups with different CAE severity.
Conclusions: It was shown for the first time that patients with CAE have higher MPVs than control subjects with normal coronary angiograms. Hence MPV might be used as a follow-up marker in patients with CAE with or without coronary artery disease.

Keywords: Platelet Activation, Hypertension, Dilatation, Pathologic - complications, Coronary Vessels, Coronary Circulation, Coronary Artery Disease - complications, Coronary Angiography, Blood Platelets - metabolism, Atherosclerosis - complications, Platelet Activation, Hypertension, Dilatation, Pathologic - complications, Coronary Vessels, Coronary Circulation, Coronary Artery Disease - complications, Coronary Angiography, Blood Platelets - metabolism, Atherosclerosis - complications

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750