01 August 2007
What’s new in the biochemical diagnosis of acute aortic dissection: Problems and perspectives
Efstratios Apostolakis, Karolina AkinosoglouMed Sci Monit 2007; 13(8): RA154-158 :: ID: 491817
Abstract
Acute aortic dissection of the thoracic aorta represents a medical emergency that, despite its rare occurrence, is characterized by severe morbidity and mortality. Prompt diagnosis is the key to a desired outcome. According to current clinical data, diagnosis is mostly based on a high index of suspicion and diagnostic imaging and less on clinical manifestations. On the other hand, a biochemical approach to the entity is still falling short in terms of diagnostic practice, although optimistic efforts are being made towards the development of such methods. Myocin heavy-chain concentrations, D-dimer levels, and soluble elastin fragment measurement are some of the new promising tools emerging in the battle of acute diagnosis. Despite their potentials, all three still need to be reevaluated. More prospective clinical trials should be performed so as to improve and ensure a biochemical diagnostic method for acute aortic dissection of high sensitivity and specificity and thus of great clinical value.
Search of the Literature: Two reviewers performed a literature search, identified the relevant studies to be included in this review, and extracted the data. Relevant studies for inclusion in this review were identified through PubMed as well as from references of the initially found articles. The search terms used were “myocin-heavy chains”, “D-dimers”, “soluble elastin fragments”, “biochemical diagnosis”, “aortic dissection”, “sensitivity”, “specificity”, and “performance characteristics”.
Keywords: Sensitivity and Specificity, Myosin Heavy Chains - chemistry, Fibrin Fibrinogen Degradation Products - biosynthesis, Elastin - metabolism, Aortic Aneurysm, Thoracic - metabolism, Aorta - pathology, Aorta - pathology, Sensitivity and Specificity, Myosin Heavy Chains - chemistry, Fibrin Fibrinogen Degradation Products - biosynthesis, Elastin - metabolism, Aortic Aneurysm, Thoracic - metabolism
Editorial
01 February 2023 : Editorial
Editorial: The XBB.1.5 (‘Kraken’) Subvariant of Omicron SARS-CoV-2 and its Rapid Global SpreadDOI: 10.12659/MSM.939580
Med Sci Monit 2023; 29:e939580
SARS-CoV-2/COVID-19
19 January 2023 : Clinical Research
Evaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...Med Sci Monit In Press; DOI: 10.12659/MSM.938892
19 January 2023 : Clinical Research
Determining the Impact of the COVID-19 Pandemic on Dental Care in the Serbian Adult Population: An Online Q...Med Sci Monit 2023; 29:e939238
27 December 2022 : Clinical Research
Effect of Physiotherapy to Correct Rounded Shoulder Posture in 30 Patients During the COVID-19 Pandemic in ...Med Sci Monit 2022; 28:e938926
10 December 2022 : Clinical Research
Retrospective Study to Identify Risk Factors for Severe Disease and Mortality Using the Modified Early Warn...Med Sci Monit 2022; 28:e938647
In Press
06 Feb 2023 : Clinical Research
Double C-Arm Digital Subtraction Angiography Guidance During Transjugular Intrahepatic Portosystemic Shunt ...Med Sci Monit In Press; DOI: 10.12659/MSM.938912
06 Feb 2023 : Review article
Evolution of Hybrid Intelligence and Its Application in Evidence-Based Medicine: A ReviewMed Sci Monit In Press; DOI: 10.12659/MSM.939366
03 Feb 2023 : Clinical Research
Treatment of Gingival Recession Defects with Pouch and Tunnel Technique Using Connective Tissue Graft and L...Med Sci Monit In Press; DOI: 10.12659/MSM.938865
02 Feb 2023 : Clinical Research
Online Questionnaire-Based Study to Evaluate the Attitudes and Use of Rubber Dental Dams by Saudi Dental Pr...Med Sci Monit In Press; DOI: 10.12659/MSM.938672
Most Viewed Current Articles
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952