Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 March 1996

Blood levels of plasminogen and alpha-2-antiplasmin in patients with prostatic carcinoma

Izabela Iwan-Ziętek, Maria Kotschy, Ewa Wiśniewska, Zbigniew Wolski

Med Sci Monit 1996; 2(2): CR183-186 :: ID: 499563

Abstract

Activation of fibrinolysis resulting in bleeding was observed in patients with prostatic carcinoma. The aim of this study was to estimate the level of plasminogen, a precursor of plasmin and α2,-antiplasmin, its main inhibitor. Blood samples were obtained from 20 patients with prostatic carcinoma and benign prostatic hyperplasia. In three patients with carcinoma massive haematuria was observed. α2,-antiplasmin activity in patients with carcinoma was found to be lower than that in patients with benign prostatic hyperplasia. Plasminogen level in both groups was normal. Additionally, routine fibrinolysis parameters were evaluated which proved to be normal except for the bleeding patients. Apart from the decreased α2,-antiplasmin activity and plasminogen level, the latter group showed a reduced euglobulin lysis time (ELT), increased level of fibrin degradation products (FDP), prolonged kaolin-kephalin time (aPTT) and low platelet count. The altered values of the parameters are, presumably, the evidence of the activation of fibrinolysis. The authors believe that patients with prostatic carcinoma are at higher risk of developing bleeding that those with benign prostatic hyperplasia.

Keywords: prostatics carcinoma, Fibrinolysis, alpha2-antiplasmin, bleeding

Add Comment 0 Comments

896 0

Editorial

01 December 2023 : Editorial  

Editorial: Outbreaks of Post-Pandemic Childhood Pneumonia and the Re-Emergence of Endemic Respiratory Infections

Dinah V. Parums

DOI: 10.12659/MSM.943312

Med Sci Monit 2023; 29:e943312

0:00

In Press

08 Dec 2023 : Clinical Research  

Association Between Influenza Vaccine Uptake and Health Awareness: A Cross-Sectional Questionnaire-Based St...

Med Sci Monit In Press; DOI:  

04 Dec 2023 : Animal Research  

Effects of Intrathecal Ketamine on Cerebrospinal Fluid Levels of Brain-Derived Neurotrophic Factor and Mech...

Med Sci Monit In Press; DOI:  

01 Dec 2023 : Clinical Research  

Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective St...

Med Sci Monit In Press; DOI:  

30 Nov 2023 : Review article  

Decoding the Neurological Sequelae of General Anesthesia: A Review

Med Sci Monit In Press; DOI:  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

0:00

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750