01 May 1996
Serum levels of endothelin and atrial natriuretic peptide (ANP) in younger middle-aged men with primary arterial hypertension treated with nifedipineHanna Lewandowska-Stanek, Ewa Jagiełło-Wójtowicz
Med Sci Monit 1996; 2(3): CR273-277 :: ID: 499786
The aim of the study was to evaluate serum endothelin and atrial natriuretic peptide (ANP) levels in 30 younger middle-aged men with primary arterial hypertension treated with nifedipine. Endothelin and ANP were determined by radioimmunoassay (RIA). To improve the evaluation of the parameters investigated the hypertensive patients were subdivided into two groups: A (smokers) and B (non-smokers). A control group consisted of 30 healthy men with body weight within normal limits. The hypertensive patients received single-drug therapy with nifedipine in a dose of 10 mg t.i.d. during their hospital stay and on an outpatient basis. The study demonstrated a significant elevation in endothelin levels in the sera of non-smoking patients with essential arterial hypertension compared to controls. At 10 days and at 3 months of nifedipine treatment endothelin levels in both smokers and non-smokers decreased to the values observed in controls. Also, a correlation between 3-month nifedipine treatment and ANP levels was observed, but exclusively in the smoking group. ANP serum levels were found to decrease in patients treated with nifedipine compared to hypertensive smokers. ANP values in nifedipine-treated patients were significantly lower from those found in normotensive smokers. The effects observed might reflect the improved haemodynamic function of the heart achieved with the control of hypertension. The correlation was not observed in non-smokers treated with nifedipine as the ANP remained at the pre-treatment levels.
Keywords: primary hypertension, natriuretic peptide, Endothelin, Nifedipine
01 November 2023 : EditorialEditorial: Factors Driving New Variants of SARS-CoV-2, Immune Escape, and Resistance to Antiviral Treatments as the End of the COVID-19 Pandemic is Declared
Med Sci Monit 2023; 29:e942960
30 Nov 2023 : Review articleDecoding the Neurological Sequelae of General Anesthesia: A Review
Med Sci Monit In Press; DOI: 10.12659/MSM.942740
30 Nov 2023 : Clinical ResearchEnhanced Pain Relief and Muscle Growth in Individuals with Low Back Instability: The Impact of Blood Flow R...
Med Sci Monit In Press; DOI: 10.12659/MSM.942508
29 Nov 2023 : Clinical ResearchComparative Analysis of Intramedullary Nail versus Plate Fixation for Fibula Fracture in Supination Externa...
Med Sci Monit In Press; DOI: 10.12659/MSM.941909
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
14 Dec 2022 : Clinical ResearchPrevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels
Med Sci Monit 2022; 28:e937990
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292