Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 July 1996

Effects of silibinin and vitamin E on lipid peroxidation and cellular immunoreactivity in experimentaly induced fatty liver of rats

Anna Blázovics, Renzo Gonzalez-Cabello, Monica Eva Horvath, Peter Gergely, Janos Feher

Med Sci Monit 1996; 2(4): BR397-403 :: ID: 499901


Free radical reactions and lipid peroxidation are proven to play an important role in the pathomechanism of the fatty liver by increasing the metabolic disorder in hyperlipidemia. The aim of the present work was to study the possible synergistic effect of silibinin and vitamin E on the deranged immune reactivity and on the lipid peroxidation in experimental hyperlipidemia in a short term experiment. Young male Wistar rats were divided into 5 groups: untreated control animals, hyperlipidemic control animals, a group treated with vitamin E (8.56 mg/kg daily for 9 days), animals treated with silibinin (25 mg/kg daily for 5 days from 4th day) which were kept on a fat rich diet and the doubly treated animals of the 5 group which were fed with a fat rich diet and treated with vitamin E and silibinin.Vitamin E and silibinin, the most commonly used natural antioxidants, can effect both the fatty liver in alimentary hyperlipidemia and immune system. Their interactions in the cytokine production, especially in the IL-1 activity in hyperlipidemia, let us conclude, that their immunostimulatory effect may be most satisfactory in regulation of lipid metabolism. Hence, the combined antioxidant and immonoregulatory effects are most efficient in hyperlipidemia.

Keywords: hyperlipidemia, Fatty Liver, immunoreactivity, Flavonoids, Vitamin E



01 October 2022 : Editorial  

Editorial: Rebound COVID-19 and Cessation of Antiviral Treatment for SARS-CoV-2 with Paxlovid and Molnupiravir

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.938532

Med Sci Monit 2022; 28:e938532


16 September 2022 : Review article  

Effects of Physiotherapy on Rehabilitation and Quality of Life in Patients Hospitalized for COVID-19: A Rev...

Med Sci Monit In Press; DOI: 10.12659/MSM.938141  

03 October 2022 : Clinical Research  

Effect of Vitamin D Concentration on Course of COVID-19

Med Sci Monit 2022; 28:e937741

In Press

03 Oct 2022 : Clinical Research  

Evaluation of Orthodontic Mini-Implant Placement in the Maxillary Anterior Alveolar Region in 15 Patients b...

Med Sci Monit In Press; DOI: 10.12659/MSM.937949  

30 Sep 2022 : Clinical Research  

Correlation Between Trough Level of Abiraterone and Prostate-Specific Antigen (PSA) Response in Metastatic ...

Med Sci Monit In Press; DOI: 10.12659/MSM.938091  

30 Sep 2022 : Review article  

A Review of the Biological Mechanisms of Dexmedetomidine for Postoperative Neurocognitive Disorders

Med Sci Monit In Press; DOI: 10.12659/MSM.937862  

29 Sep 2022 : Animal Research  

Effect of Antilogous Platelet-Rich Plasma on the Revascularization of Rabbit Prefabricated Flap

Med Sci Monit In Press; DOI: 10.12659/MSM.937718  

Most Viewed Current Articles

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Nov 2020 : Review article  

Long-Term Respiratory and Neurological Sequelae of COVID-19

DOI :10.12659/MSM.928996

Med Sci Monit 2020; 26:e928996

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750