Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

02 September 1996

Detection of high and low risk Human Papilloma Virus (HPV) DNA in high grade cervical dysplasia and cancer by in situ hybridization - a comparative study

Iwona Mielżyńska, Zbigniew Szczurek, Daniel Sabat

Med Sci Monit 1996; 2(5): CR587-592 :: ID: 500057

Abstract

An etiological relation between HPV infection and the development of dysplastic and neoplastic changes in the uterine cervix has been documented by many investigators all over the world who used new methods for detecting viral DNA in biological examinations. Lack of Polish studies prompted us to undertake similar investigations. We studied 33 cases including 6 severe dysplasias, 5 carcinomas in situ and 22 invasive squamous cell carcinoma of the cervix. In situ hybridization with the use Digene Tissue Hybridization Kit and Omni Probe Set revealed viral HPV DNA in 24 cases including 4 severe dysplasias, 3 in situ carcinomas and 17 invasive carcinomas. All positive cases were analysed with respect to the risk level (types 6,11,42,43,44). They showed the presence of DNA of high risk viruses in all cases and in one case DNA of low risk viruses. A total of 72,2% patients with severe dysplasia and squamous cell cervical carcinoma showed the presence of HPV DNA. The present findings confirm the great role of high risk HPV infection for cervical cancer development in the investigated group of Polish women.

Keywords: HPV virus, cervical dysplasia and cancer, In Situ Hybridization

Add Comment 0 Comments

668 0

Editorial

01 November 2023 : Editorial  

Editorial: Factors Driving New Variants of SARS-CoV-2, Immune Escape, and Resistance to Antiviral Treatments as the End of the COVID-19 Pandemic is Declared

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville,

DOI: 10.12659/MSM.942960

Med Sci Monit 2023; 29:e942960

0:00

In Press

30 Nov 2023 : Review article  

Decoding the Neurological Sequelae of General Anesthesia: A Review

Med Sci Monit In Press; DOI:  

30 Nov 2023 : Clinical Research  

Enhanced Pain Relief and Muscle Growth in Individuals with Low Back Instability: The Impact of Blood Flow R...

Med Sci Monit In Press; DOI:  

29 Nov 2023 : Clinical Research  

Comparative Analysis of Intramedullary Nail versus Plate Fixation for Fibula Fracture in Supination Externa...

Med Sci Monit In Press; DOI:  

29 Nov 2023 : Clinical Research  

Impact of COVID-19 on Academic Burnout among Medical College Students in China: Findings from a Web-Based S...

Med Sci Monit In Press; DOI:  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

0:00

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750