Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 January 1997

In vitro and in vivo pharmacology of novel naltrindole-related compounds

András Z. Rónai, Klára Gyires, Helmut Schmidhammer, Sándor Hosztafi, Anna Borsodi, Marianna Spetea, Tamás Friedmann, Pál Riba, Zsuzsanna Fürst

Med Sci Monit 1997; 3(1): RA1-5 :: ID: 500585


The pharmacological and receptor binding properties of some novel naltrindole (NTI) and naltrexone benzofurane (NTB) derivatives, modified at positions 3, 5, 14 and 17 were studied. Of the N-(17)-methyl NTI-derivatives, the 14-O-methyl derivative was a potent, highly selective d opioid agonist whereas the 5-methyl derivative of the latter was a moderately potent m agonist. Of the N-(17)-methyl NTB derivatives the 3, 14-OH compound was a potent antagonist whereas the 3-O-methyl, 14-OH derivative was a moderately potent mixed agonist/antagonist at the same receptor. The N-methyl, 14-Omethyl NTI derivative (‘morphindole’) had in vivo a potent gastroprotective effect in rats in the ethanol-induced ulcer model.

Keywords: N-methyl naltrindole-derivatives (morphindoles), isolated organs, N-methyl naltrexone-benzofurane, gastroprotective effect

Add Comment 0 Comments

541 6


01 June 2023 : Editorial  

Editorial: Infectious Disease Surveillance Using Artificial Intelligence (AI) and its Role in Epidemic and Pandemic Preparedness

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.941209

Med Sci Monit 2023; 29:e941209


In Press

07 Jun 2023 : Review article  

Ultrasound-Guided Brachial Plexus Block by Costoclavicular Space Approach: A Narrative Review

Med Sci Monit In Press; DOI: 10.12659/MSM.939920  

05 Jun 2023 : Clinical Research  

Comparison of Texture and Color Enhancement Imaging with White Light Imaging in 52 Patients with Short-Segm...

Med Sci Monit In Press; DOI: 10.12659/MSM.940249  

05 Jun 2023 : Laboratory Research  

Comparison of Composite Resin (Duo-Shade) Shade Guide with Vita Ceramic Shades Before and After Chemical an...

Med Sci Monit In Press; DOI: 10.12659/MSM.940949  

02 Jun 2023 : Database Analysis  

The COVID-19 Crisis and the Incidence of Alcohol-Related Deaths in Poland

Med Sci Monit In Press; DOI: 10.12659/MSM.940904  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788


30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750