Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

03 March 1997

Early side effects on normal tissue of radiotherapy for head and neck cancers correlation with activities of free radical scavenging enzymes

Dorota Tarnawska, Krzysztof Składowski, Wojciech Jacheć, Roman Tarnawski, Andrzej Tomasik, Bogusław Maciejewski

Med Sci Monit 1997; 3(2): CR199-203 :: ID: 500692

Abstract

Early side effects of radiation therapy seem to be a major limiting factor in treatment intensification for head and neck cancers. Correlations between the activity of Cu,Zn-superoxide dismutase (SOD), gluthatione peroxidase (GPX), gluthatione transferase (GST); the concentration of malonyldialdehyde (MDA), 7-ketocholesterol, and the severity of early mucosal radiation damage were studied in 90 patients treated with radical radiotherapy. Mucosal reactions were scored according to the Dische scale. Enzymatic activities were studied in erythrocytes, and concentrations of lipid oxidation were measured in blood plasma. The mean Cu,Zn-SOD activity before treatment was 947 U/g Hb, mean GPX activity 21 U/g Hb, MDA concentration in plasma 4.2 µg/l, MDA concentration in erythrocytes 0.19 µg/g Hb, and 7-ketocholesterol concentration 228 µg/l. Only gluthatione peroxidase (r=0.54) and gluthatione peroxidase/superoxide dismutase activity ratio (r=0.52) correlated with the severity of clinically observed early radiation damage. As a wide spectrum of the enzymatic activities was observed for the same level of normal tissue injury, it is not possible to predict the clinical radiosensitivity of individual patients from the estimation of the free radical enzymatic scavenging activity.

Keywords: radiation injury, Radiotherapy, gluthatione peroxidase, oxygen free radicals, Dose Fractionation

Add Comment 0 Comments

Editorial

01 July 2024 : Editorial  

Editorial: The Global Threats of Increasing Antimicrobial Resistance Require New Approaches to Drug Development, Including Molecular Antimicrobial Adjuvants

Dinah V. Parums

DOI: 10.12659/MSM.945583

Med Sci Monit 2024; 30:e945583

0:00

In Press

Clinical Research  

Cost-Effectiveness Analysis of Hepatic Arterial Chemotherapy for Advanced Hepatocellular Carcinoma in China...

Med Sci Monit In Press; DOI: 10.12659/MSM.944526  

0:00

Clinical Research  

Comparative Analysis of Antihypertensive and Anticonvulsant Regimens in Managing Pre-eclampsia and Eclampsi...

Med Sci Monit In Press; DOI: 10.12659/MSM.944985  

Clinical Research  

Reduced Radial Artery Occlusion in Transradial Cerebral Angiography: Key Predictive Factors and Preventive ...

Med Sci Monit In Press; DOI: 10.12659/MSM.944297  

Database Analysis  

Enhanced Outcomes in Femoral Subtrochanteric Fractures Using Long INTERTAN Nails with Titanium Cable Cercla...

Med Sci Monit In Press; DOI: 10.12659/MSM.944383  

Most Viewed Current Articles

17 Jan 2024 : Review article   4,116,598

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research   1,594,331

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

16 May 2023 : Clinical Research   691,000

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Jan 2022 : Editorial   50,822

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750