In most cases, the determination of immunological condition of patients is vital from the perspective of the course of the disease and its treatment. Patients with osteoporosis of 3rd degree form a selected group while the division into osteoporosis type I in women after menopause and osteoporosis type II in elderly patients is arbitrary. The aim of this research was to find the discriminating parameter of immune reactivity for osteoporosis of 3rd degree. Abnormal proportion of cells CD4:CD8 (1.0) was shown in 40% cases. In addition, the increased ability of T cells and their subpopulations to form non-immune rosettes with SRBC was observed. Neutropenia was diagnosed in 8 patients (40%) and NBT-sp test showed the values of NBT-positive cells to be 3 or 4 times higher. The results confirm our assumptions and support the value of immunomodulating treatment in ubiquitin therapy.

Keywords: Osteoporosis, Immune System, immune reactivity, laboratory evaluation