01 May 1997
Haemopexin and uptake of haem by human erythroleukemia (HEL) cellsHana Cajthamlova, Zbynek Hrkal, Dana Grebenova, Ursula Muller-Eberhard, Richard J. Stockert
Med Sci Monit 1997; 3(3): BR305-312 :: ID: 500777
Uncomplexed haem suppresses the proliferation of human erythroleukemia (HEL) cells, the effect of which can be partially reversed by apo-haemopexin. The process of suppressed proliferation is paralleled by differentiation of the HEL cells accompanied by haemoglobin synthesis. Equivalent amounts of haem supplied to the cells in the form of haem-haemopexin neither affected their proliferation nor promoted haemoglobin synthesis. Haemopexin internalization by HEL cells only occurred if the haem-haemopexin complexes were continuously supplied to the cells at 37 °C. It suggests that fluid flow endocytosis rather than receptor mediated endocytosis is operative in this process.
Keywords: haem, haemopexin, HEL, proliferation, receptor
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