01 July 1997
Effects of selected metalloporphyrins on the proliferation of human colorectal carcinomaPetr Pohlreich, Jana Stribrna, Jaromr Kremen, Pavel Martasek
Med Sci Monit 1997; 3(4): BR460-464 :: ID: 501322
Heme oxygenase is an enzyme responsible for the rate-limiting step in the oxidative degradation of heme. Inducible and constitutive forms of heme oxygenase (HO-1 and HO-2) have been characterized. Compared with normal liver and kidney tissue, human colorectal carcinoma propagated in athymic nude mice demonstrated an increase in heme oxygenase activity. The enzyme activity in tumors was significantly inhibited after intraperitoneal administration of synthetic metalloporphyrins, zinc-deuteroporphyrin IX-2,4-bisglycol and cobalt-protoporphyrin. Application of metalloporphyrins led to simultaneous stimulation of tumor growth.
Keywords: heme oxygenase, Colorectal Carcinoma, Metalloporphyrins, Thymidine Kinase, Hemin
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