Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 September 1997

Gamma-sigma+ T cells and humoral response to hsp 65 and hsp 70 in subacute sclerosing panencephalitis

Urszula Fiszer, Grażyna Korczak-Kowalska, Wanda Sobczyk, Wanda Sobczyk

Med Sci Monit 1997; 3(5): CR677-681 :: ID: 501590

Abstract

Several hypothesis have been put forward to explain the pathogenesis of subacute sclerosing panencephalitis (SSPE). However, the mechanisms leading to the lack of elemination of the virus still remain unclear. Due to the protection function of gd+ T cells in infections, the present investigation examined the percent of gd+ T cells out of all T cells and their characteristics in peripheral blood by flow cytometry. Heat shock proteins (hsps) play an important role in the response of neurons to different factors, therefore the existence of IgG and IgM antibodies against hsps in sera was examined by the ELISA in 14 patients with SSPE. These investigations were also carried out on a control group patients with other neurological diseases (OND). In SSPE patients the average percentage of gd+ T lymphocytes in the peripheral blood was higher (6.9±5.4%) in comparison with OND (1.9±1.9%). The percentage of subtype Vd1/gd+ T cells amounted to 18.5±17.0% in the SSPE patients and to 33.5±27.1% in OND. Active gd+ T cells (CD25+gd+T) were found in 2 of 12 patients with SSPE and in 5 of 14 patients with OND. No differences were found between mean ELISA ratios for IgG and IgM antibodies in the sera of SSPE and OND patients tested for antibodies against hsp 65 and hsp 70. The above data comes from patients with advanced disease treated with immunomodulatory drugs; they confirm a disturbances of cell response in patients with SSPE.

Keywords: gamma-sigma+ T cells, heat shock proteins, SSPE

0 Comments

Editorial

01 August 2022 : Editorial  

Editorial: Long-Term Effects of Symptomatic and Asymptomatic SARS-CoV-2 Infection in Children and the Changing Pathogenesis of Common Childhood Viruses Driven by the COVID-19 Pandemic

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.937927

Med Sci Monit 2022; 28:e937927

In Press

08 Aug 2022 : Clinical Research  

A 3-Year Clinical Evaluation of Endodontically Treated Posterior Teeth Restored with Resin Nanoceramic Comp...

Med Sci Monit In Press; DOI: 10.12659/MSM.937331  

08 Aug 2022 : Clinical Research  

Hemoglobin/Red Blood Cell Distribution Width Ratio in Peripheral Blood Is Positively Associated with Progno...

Med Sci Monit In Press; DOI: 10.12659/MSM.937146  

05 Aug 2022 : Clinical Research  

A Retrospective Study of 98 Elderly Patients with High-Risk Lateral Femoral Wall Intertrochanteric Hip Frac...

Med Sci Monit In Press; DOI: 10.12659/MSM.936923  

04 Aug 2022 : Clinical Research  

Radiological Assessment of Prevalance and Quality of Periapical Status of Endodontic Treatments

Med Sci Monit In Press; DOI: 10.12659/MSM.936569  

Most Viewed Current Articles

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Nov 2020 : Review article  

Long-Term Respiratory and Neurological Sequelae of COVID-19

DOI :10.12659/MSM.928996

Med Sci Monit 2020; 26:e928996

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750