01 September 1997
Gamma-sigma+ T cells and humoral response to hsp 65 and hsp 70 in subacute sclerosing panencephalitisUrszula Fiszer, Grażyna Korczak-Kowalska, Wanda Sobczyk, Wanda Sobczyk
Med Sci Monit 1997; 3(5): CR677-681 :: ID: 501590
Several hypothesis have been put forward to explain the pathogenesis of subacute sclerosing panencephalitis (SSPE). However, the mechanisms leading to the lack of elemination of the virus still remain unclear. Due to the protection function of gd+ T cells in infections, the present investigation examined the percent of gd+ T cells out of all T cells and their characteristics in peripheral blood by flow cytometry. Heat shock proteins (hsps) play an important role in the response of neurons to different factors, therefore the existence of IgG and IgM antibodies against hsps in sera was examined by the ELISA in 14 patients with SSPE. These investigations were also carried out on a control group patients with other neurological diseases (OND). In SSPE patients the average percentage of gd+ T lymphocytes in the peripheral blood was higher (6.9±5.4%) in comparison with OND (1.9±1.9%). The percentage of subtype Vd1/gd+ T cells amounted to 18.5±17.0% in the SSPE patients and to 33.5±27.1% in OND. Active gd+ T cells (CD25+gd+T) were found in 2 of 12 patients with SSPE and in 5 of 14 patients with OND. No differences were found between mean ELISA ratios for IgG and IgM antibodies in the sera of SSPE and OND patients tested for antibodies against hsp 65 and hsp 70. The above data comes from patients with advanced disease treated with immunomodulatory drugs; they confirm a disturbances of cell response in patients with SSPE.
Keywords: gamma-sigma+ T cells, heat shock proteins, SSPE
01 February 2023 : EditorialEditorial: The XBB.1.5 (‘Kraken’) Subvariant of Omicron SARS-CoV-2 and its Rapid Global Spread
Med Sci Monit 2023; 29:e939580
19 January 2023 : Clinical ResearchEvaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...
Med Sci Monit In Press; DOI: 10.12659/MSM.938892
19 January 2023 : Clinical ResearchDetermining the Impact of the COVID-19 Pandemic on Dental Care in the Serbian Adult Population: An Online Q...
Med Sci Monit 2023; 29:e939238
27 December 2022 : Clinical ResearchEffect of Physiotherapy to Correct Rounded Shoulder Posture in 30 Patients During the COVID-19 Pandemic in ...
Med Sci Monit 2022; 28:e938926
01 Feb 2023 : Clinical ResearchComparison of 3 Enzyme-Linked Immunoassay Methods to Evaluate Serum Concentrations of Infliximab and Antibo...
Med Sci Monit In Press; DOI: 10.12659/MSM.939084
31 Jan 2023 : Clinical ResearchBalloon Dilation Eustachian Tuboplasty Combined with Tympanotomy Tube Insertion for Treatment of Refractory...
Med Sci Monit In Press; DOI: 10.12659/MSM.938879
31 Jan 2023 : Clinical ResearchComparison of Vision Correction and Corneal Thickness at 180-Day Follow-Up After Femtosecond Laser-Assisted...
Med Sci Monit In Press; DOI: 10.12659/MSM.939099
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292