01 September 1998
Role of histamine H3-receptors in the proliferation of neoplastic cells in vitro
Adam SzelągMed Sci Monit 1998; 4(5): BR747-755 :: ID: 501958
Abstract
The study was devoted to the investigation of the effect of tioperamide and clobenpropit - the antagonists, as well as R-alpha-methylhistamine and imetit - the agonists of histamine H3 receptors on the proliferation of neoplastic cells in vitro. The study was performed upon the following cell lines: BM - human melanoma, A-431 - human cutaneous carcinoma, TT - human medullary thyroid carcinoma, Ta3Hauszka - mammary cancer of mice, F6B¸Y - normal bovine foetal thyroid. For each cell line, test value (TV) and test index (TI) were determined according to generally-used criteria. The study presented in our paper is the first attempt to use the modulation of histamine H3 receptors in the regulation of neoplastic cells proliferation. It was demonstrated that antagonists of histamine H3 receptors - tioperamide and clobenpropit considerably inhibit the proliferation of the cells of human neoplasms - melanoma and cutaneous carcinoma. An opposite effect was observed in the case of the agonists of these receptors - R-alpha-methylhistamine and imetit - which very clearly stimulate proliferation of these neoplastic cells. Non-neoplastic cells of normal bovine thyroid are slightly sensitive to the inhibiting activity of antagonists as well as to proliferation stimulating activity of the agonists of these receptors. The activity of the studied compounds may be associated with H3 receptors, since the antagonists of these receptors inhibit proliferating action of agonists. These observations suggest that mediators released after the use of the antagonists of these receptors, or intracellular changes taking place as an effect of their action, slow down the proliferation of neoplastic cells, but not normal cells.
Keywords: proliferation of neoplastic cells, H3 receptors
Editorial
01 March 2023 : Editorial
Editorial: Global Surveillance of Highly Pathogenic Avian Influenza Viruses in Poultry, Wild Birds, and Mammals to Prevent a Human Influenza PandemicDOI: 10.12659/MSM.939968
Med Sci Monit 2023; 29:e939968
SARS-CoV-2/COVID-19
29 March 2023 : Editorial
Editorial: Effective Direct-Acting Antiviral Treatments Support Global and National Programs to Eliminate H...Med Sci Monit In Press; DOI: 10.12659/MSM.940519
30 March 2023 : Clinical Research
An Online Survey on the Relationship Between Positive Coping and Post-Traumatic Stress Symptoms (PTSS) of M...Med Sci Monit In Press; DOI: 10.12659/MSM.939485
09 February 2023 : Clinical Research
Evaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...Med Sci Monit 2023; 29:e938892
19 January 2023 : Clinical Research
Determining the Impact of the COVID-19 Pandemic on Dental Care in the Serbian Adult Population: An Online Q...Med Sci Monit 2023; 29:e939238
In Press
30 Mar 2023 : Clinical Research
An Online Survey on the Relationship Between Positive Coping and Post-Traumatic Stress Symptoms (PTSS) of M...Med Sci Monit In Press; DOI: 10.12659/MSM.939485
30 Mar 2023 : Database Analysis
Global Research Trends and Hotspots in Lateral Epicondylitis During the Past 30 Years: A Bibliometric and V...Med Sci Monit In Press; DOI: 10.12659/MSM.939309
29 Mar 2023 : Editorial
Editorial: Effective Direct-Acting Antiviral Treatments Support Global and National Programs to Eliminate H...Med Sci Monit In Press; DOI: 10.12659/MSM.940519
29 Mar 2023 : Laboratory Research
Preparation, Physicochemical Properties, and Structural Characterization of Resistant Starch-Aspirin-Loaded...Med Sci Monit In Press; DOI: 10.12659/MSM.939711
Most Viewed Current Articles
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952