Logo Medical Science Monitor

Call: +1.631.470.9640
Closed: National Holiday

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 September 1998

Effect of radiotherapy and surgery on glyoxalase activities in larynx cancer patient erythrocytes

Danuta Piskorska, Alojzy Danch, Marian Dró—żdż, Ewa Kopieczna-Grzebieniak, Grzegorz Namysłowski, Eugeniusz Czecior, Ewa Nowińska

Med Sci Monit 1998; 4(5): CR840-845 :: ID: 502039

Abstract

The glyoxalase system is modulated during cell division and differentiation and may also play an important role in cellular radiosensitivity. Glyoxalase I and glyoxalase II metabolize methylglyoxal to D-lactic acid, via D-lactoylglutathione.The glyoxalase enzymes activities were measured in erythrocytes of 17 healthy subjects and 41 patients with cancer of the larynx. The activities of glyoxalase I and glyoxalase II were decreased in the patients group in comparison to the control group and were as follows: 31.47±6.66 mU/mg protein and 11.73±3.21 mU/mg protein, respectively (control group: 42.40±7.28 and 19.66±2.62), (p< 0.0001). The activities of both glyoxalase I and glyoxalase II increased in patient erythrocytes following radiotherapy and in patients following combined therapy - surgery and radiotherapy. This was not so following surgery in comparison to enzymes activities in patients with cancer of the larynx cancer before therapy. The changes in glyoxalases activities following radiotherapy did not significantly differ from control group glyoxalase I and glyoxalase II activities.These results suggest that the glyoxalase system is affected by erythrocytes radiation.

Keywords: glyoxalases, cancer of the larynx, Radiotherapy

Add Comment 0 Comments

Editorial

01 November 2024 : Editorial  

Editorial: Artificial Intelligence (AI), Digital Image Analysis, and the Future of Cancer Diagnosis and Prognosis

Dinah V. Parums

DOI: 10.12659/MSM.947038

Med Sci Monit 2024; 30:e947038

0:00

In Press

Clinical Research  

Iliac Periosteal Bone Autografting vs Talus Non-Weight-Bearing Surgery in Hepple V Talus Osteochondral Inju...

Med Sci Monit In Press; DOI: 10.12659/MSM.944912  

Clinical Research  

Impact of Different Orthodontic Appliances on Mandibular Condyle, Anterior Region of Mandibular, and Maxill...

Med Sci Monit In Press; DOI: 10.12659/MSM.946265  

Clinical Research  

Risk Factors for Bone Cement Displacement After Percutaneous Kyphoplasty in Osteoporotic Vertebral Fracture...

Med Sci Monit In Press; DOI: 10.12659/MSM.945884  

Clinical Research  

Adipose-Derived Mesenchymal Stem Cells from Arthritis Patients: Differential Modulation of CD4⁺ T Cell Acti...

Med Sci Monit In Press; DOI: 10.12659/MSM.945273  

Most Viewed Current Articles

17 Jan 2024 : Review article   6,407,835

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research   1,909,112

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

16 May 2023 : Clinical Research   695,529

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

07 Jan 2022 : Meta-Analysis   260,637

Efficacy and Safety of Light Therapy as a Home Treatment for Motor and Non-Motor Symptoms of Parkinson Dise...

DOI :10.12659/MSM.935074

Med Sci Monit 2022; 28:e935074

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750