Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 July 1998

GABA content and GAD activity in normal mouse mammary gland tissue and in 16/C mammary cancer cells

Maria Mazurkiewicz, Adam Opolski, Joanna Wietrzyk, Czesław Radzikowski, Zdzisław Kleinrok

Med Sci Monit 1998; 4(4): BR596-599 :: ID: 502105

Abstract

GABA ((-aminobutyric acid) is the brain's main inhibitory neurotransmitter. The highest level of GABA is found in the CNS. GABA presence and GAD (the key enzyme in GABA synthesis) activity were also detected in several non-neural tissues. We observed an increase in the GABA level and GAD activity in tumor tissues in comparison with normal tissue. Our study examined the GABA content and GADactivity in the normal mammary gland of healthy mice and in the 16/C adenocarcinoma mammary gland as an experimental model. Comparison between and within groups were made by one way analysis of variance (ANOVA). Our investigations demonstrated GABA presence and GAD activity in the normal mouse mammary gland tissue. We observed a significant increase in the GABA level and GAD activity in mouse 16/C mammary cancer cells in comparison with normal mammary gland skin. Tumor tissues showed a clear positive correlation between GABA levels and GAD activity. There were no significant differences in the GABA content and GAD activity between mammary gland skin coming from tumor bearing and healthy mice. An increase of the GABA level and GAD activity in tumor tissues could possibly reflect a local antitumor response, however, hypoxia of tumor cells could also be considered. The observed GABA metabolism pathway in mammary cancer compared with literature data concerning other tumors, can suggest the possibility of therapeutic usefulness of GABA-ergic system agonists such as baclophen.

Keywords: Neoplasms, breast cancer, Adenocarcinoma, GABA, GAD

0 Comments

Editorial

04 June 2022 : Editorial  

Editorial: Acute Hepatitis of Unknown Origin in Children. Is Autoimmunity at Play?

Nahum Mendez-Sanchez, Shreya C. Pal
Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico

DOI: 10.12659/MSM.937371

Med Sci Monit 2022; 28:e937371

SARS-CoV-2/COVID-19

27 June 2022 : Clinical Research  

Shoulder Injury Related to Vaccine Administration (SIRVA) in 16 Patients Following COVID-19 Vaccination Who...

Med Sci Monit In Press; DOI: 10.12659/MSM.937430  

27 May 2022 : Clinical Research  

Factors Associated with Falls During Hospitalization for Coronavirus Disease 2019 (COVID-19)

Med Sci Monit 2022; 28:e936547

In Press

30 Jun 2022 : Clinical Research  

Antioxidant System and Ions Concentrations After Femoral Neck and Resurfacing Hip Arthroplasty

Med Sci Monit In Press; DOI: 10.12659/MSM.936335  

28 Jun 2022 : Meta-Analysis  

Urodynamics in Early Diagnosis of Diabetic Bladder Dysfunction in Women: A Systematic Review and Meta-Analysis

Med Sci Monit In Press; DOI: 10.12659/MSM.937166  

28 Jun 2022 : Clinical Research  

Serum Calprotectin – a NET Product – as a Biomarker of Disease Activity in Patients with Systemic Lupus Ery...

Med Sci Monit In Press; DOI: 10.12659/MSM.936534  

28 Jun 2022 : Database Analysis  

LINC00963 May Be Associated with a Poor Prognosis in Patients with Cervical Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.935070  

Most Viewed Current Articles

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Nov 2020 : Review article  

Long-Term Respiratory and Neurological Sequelae of COVID-19

DOI :10.12659/MSM.928996

Med Sci Monit 2020; 26:e928996

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750