01 July 1998
Soluble HLA-A and HLA-B antigens in children with congenital adrenal hyperplasia (CAH) and the classic form of 21-hydroxylase deficiency
Gabriel Turowski, Danuta Gieracka-Pażucha, Dorota Turowska-Heydel, Jacek J PietrzykMed Sci Monit 1998; 4(4): CR633-639 :: ID: 502127
Abstract
It seems important to recognize the function and role of soluble histocompatibility antigens in the pathogenesis of a disease. This especially concerns HLA antigen concentration levels (sHLA-1) in their different allogenic expression. We have tried to determine the phenotypic sHLA-1 concentration levels in 48 children with CAH (the classic form of 21-hydroxylase deficiency). In the first stage of the experiment we determined the appearance of CAH HLA-A, B, C lymphocyte antigens in comparison with 1152 healthy individuals. We noted a statistically high titer of HLA-B47, B61 (40), A3 antigens in CAH children and a lower frequency occurance for HLA- A24 (9) and Bw 6 antigens. We then determined the sHLA-I concentration levels from the serum of CAH children and the results obtained were presented as a total number of points for the inhibition of the cytotoxic reaction as well as the relative 'A' value and the sHLA ÐI concentration levels in 1 ml of serum. SHLA-I concentration levels obtained from healthy individuals served as comparison analysis. SHLA-I concentration levels in CAH children are shown in tables III-VI. Soluble HLA-I antigens from the serum of CAH children demonstrate incorrect concentration level values in comparison with sHLA-I antigens of healthy individuals.
Keywords: congenital adrenal hyperplasia, Pathology, soluble HLA antigens, HLA-ABC antigens frequency
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
18 Mar 2024 : Clinical Research
Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative StudyMed Sci Monit In Press; DOI: 10.12659/MSM.944136
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952