Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 July 1998

Superoxide dismutase isoenzymes activity changes in the plasma of heart failure patients

Wojciech Jacheć, Lech Poloński, Barbara Kuśnierz, Roman Tarnowski, Jan Wodnicki, Michał Tendera, Andrzej Tomasik

Med Sci Monit 1998; 4(4): CR646-650 :: ID: 502284


46 patients (19 women and 27 men, aged 42±14 years) with congestive cardiomyopathy (left ventricular ejection
fraction < 30%) and 10 healthy subjects (aged 36±12 years) were evaluated echocardiographically.Plasma activities of MnSOD and CuZnSOD were measured. A statistically significant negative correlation was found between MnSOD activity and the CI (r=0.64). The mean MnSOD activity in patients with the CI<2.41/min/m2 was 16.58±5.82 NU/I, and in patients with the CI>2.41/min/m2 it was 9.92±3.28NU/I (p<0.001). The mean CuZnSOP activity in patients with the CI<2.41/min/m2 was 4.5NU/I and in patients with CI>2.41/min/m2 it was 6.9±2.32 (p<0.01). The activity of MnSOD and CuZnSOD in healthy subjects was comparable to that found in patients with the CI>2.41/min/m2. Patients with the CI<2.41/min/m2 were reexamined following 6 weeks of pharmacological treatment (Drugs used: digoxin, captopril, furosemide, isosorbide dinitrate). A significant increase of the CI (p<0.01) accompanied by a decrease of MnSOD activity (p<0.05), and an insignificant increase of CuZnSOD activity were found. Our results indirectly confirm the increase of oxygen free radical concentration levels in patients with heart failure.

Keywords: Heart Failure, cardiomyopathy, Free Radicals, Superoxide Dismutase, Isoenzymes



01 July 2022 : Editorial  

Editorial: World Health Organization (WHO) Variants of Concern Lineages Under Monitoring (VOC-LUM) in Response to the Global Spread of Lineages and Sublineages of Omicron, or B.1.1.529, SARS-CoV-2

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.937676

Med Sci Monit 2022; 28:e937676


27 June 2022 : Clinical Research  

Shoulder Injury Related to Vaccine Administration (SIRVA) in 16 Patients Following COVID-19 Vaccination Who...

Med Sci Monit In Press; DOI: 10.12659/MSM.937430  

27 May 2022 : Clinical Research  

Factors Associated with Falls During Hospitalization for Coronavirus Disease 2019 (COVID-19)

Med Sci Monit 2022; 28:e936547

In Press

05 Jul 2022 : Clinical Research  

Attention-Deficit/Hyperactivity Disorder (ADHD) and Time Perception in Adults: Do Adults with Different ADH...

Med Sci Monit In Press; DOI: 10.12659/MSM.936849  

01 Jul 2022 : Clinical Research  

Does Early-Period Patient Dissatisfaction Turn Into Satisfaction Over Time After Total Knee Replacement?

Med Sci Monit In Press; DOI: 10.12659/MSM.936792  

30 Jun 2022 : Laboratory Research  

Bcl-2 19-kDa Interacting Protein 3 (BNIP3)-Mediated Mitophagy Attenuates Intermittent Hypoxia-Induced Human...

Med Sci Monit In Press; DOI: 10.12659/MSM.936760  

30 Jun 2022 : Clinical Research  

Antioxidant System and Ions Concentrations After Femoral Neck and Resurfacing Hip Arthroplasty

Med Sci Monit In Press; DOI: 10.12659/MSM.936335  

Most Viewed Current Articles

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

01 Nov 2020 : Review article  

Long-Term Respiratory and Neurological Sequelae of COVID-19

DOI :10.12659/MSM.928996

Med Sci Monit 2020; 26:e928996

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750