Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 July 1998

Superoxide dismutase isoenzymes activity changes in the plasma of heart failure patients

Wojciech Jacheć, Lech Poloński, Barbara Kuśnierz, Roman Tarnowski, Jan Wodnicki, Michał Tendera, Andrzej Tomasik

Med Sci Monit 1998; 4(4): CR646-650 :: ID: 502284


46 patients (19 women and 27 men, aged 42±14 years) with congestive cardiomyopathy (left ventricular ejection
fraction < 30%) and 10 healthy subjects (aged 36±12 years) were evaluated echocardiographically.Plasma activities of MnSOD and CuZnSOD were measured. A statistically significant negative correlation was found between MnSOD activity and the CI (r=0.64). The mean MnSOD activity in patients with the CI<2.41/min/m2 was 16.58±5.82 NU/I, and in patients with the CI>2.41/min/m2 it was 9.92±3.28NU/I (p<0.001). The mean CuZnSOP activity in patients with the CI<2.41/min/m2 was 4.5NU/I and in patients with CI>2.41/min/m2 it was 6.9±2.32 (p<0.01). The activity of MnSOD and CuZnSOD in healthy subjects was comparable to that found in patients with the CI>2.41/min/m2. Patients with the CI<2.41/min/m2 were reexamined following 6 weeks of pharmacological treatment (Drugs used: digoxin, captopril, furosemide, isosorbide dinitrate). A significant increase of the CI (p<0.01) accompanied by a decrease of MnSOD activity (p<0.05), and an insignificant increase of CuZnSOD activity were found. Our results indirectly confirm the increase of oxygen free radical concentration levels in patients with heart failure.

Keywords: Heart Failure, cardiomyopathy, Free Radicals, Isoenzymes



01 January 2023 : Editorial  

Editorial: Current Status of Two Adjuvanted Malaria Vaccines and the World Health Organization (WHO) Strategy to Eradicate Malaria by 2030

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.939357

Med Sci Monit 2023; 29:e939357


26 January 2023 : Editorial  

Editorial: The XBB.1.5 (‘Kraken’) Subvariant of Omicron SARS-CoV-2 and its Rapid Global Spread

Med Sci Monit In Press; DOI: 10.12659/MSM.939580  

19 January 2023 : Clinical Research  

Evaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...

Med Sci Monit In Press; DOI: 10.12659/MSM.938892  

27 December 2022 : Clinical Research  

Effect of Physiotherapy to Correct Rounded Shoulder Posture in 30 Patients During the COVID-19 Pandemic in ...

Med Sci Monit 2022; 28:e938926

In Press

31 Jan 2023 : Clinical Research  

Balloon Dilation Eustachian Tuboplasty Combined with Tympanotomy Tube Insertion for Treatment of Refractory...

Med Sci Monit In Press; DOI: 10.12659/MSM.938879  

31 Jan 2023 : Clinical Research  

Comparison of Vision Correction and Corneal Thickness at 180-Day Follow-Up After Femtosecond Laser-Assisted...

Med Sci Monit In Press; DOI: 10.12659/MSM.939099  

30 Jan 2023 : Clinical Research  

Splenic Artery Steal Syndrome in Patients with Liver Cirrhosis: A Retrospective Clinical Study

Med Sci Monit In Press; DOI: 10.12659/MSM.938998  

27 Jan 2023 : Database Analysis  

Association Between Neutrophil-Lymphocyte Ratio and All-Cause Mortality in Critically Ill Patients with Chr...

Med Sci Monit In Press; DOI: 10.12659/MSM.938554  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750