The purpose of the study was to compare the efficiency and tolerance of Augmentin¨ and cefuroxime in the treatment of chronic maxillary sinusitis based on clinical and bacteriological results. A group of l15 adults with radiographically and clinically confirmed maxillary sinusitis constituted the study group. The safety of the antimicrobials was also analyzed. Patients underwent maxillary sinus aspiration twice. . Prior to the initiation of treatment sinus fluid was aspirated and sent to the laboratory. Patients were then randomized to treatment with either Augmentin¨ or cefuroxime. A second sinus puncture was performed at the end of the fourteen-day treatment. Microbiological assessment was performed again. The clinical cure rate for Augmentin¨ and cefuroxime was determined to be 98.2% and 91.1%, respectively. No significant dependence in efficacy between the two antibiotics was shown by Fisher's exact test (p=0.20). Microbiological cure was about 69%. The results indicate good efficacy for both antibiotics in the treatment of chronic sinusitis and similar very acceptable clinical tolerance

Keywords: chronic sinusitis, sinus puncture, treatment, Augmentin, Cefuroxime