Introduction: The aim of this study was to investigate the different methods of 20% Mannitol administration on the occurrence of early diuresis in kidney graft recipients as well as on long-term kidney transplantation results. Early diuresis was defined as diuresis that exceeded the patient's own kidneys excretory function of 30 ml/kg b.m before the graft transplantation. Methods: 42 patients (21 pairs) - kidney graft recipients in 1994 - were included in the study. Each patient from a given pair received one kidney from the same donor. Both recipients from each pair were randomly included in one of the two groups. An appropriate volume of Mannitol was administered before kidney reperfusion in group I, and in group II Mannitol was administered following graft reperfusion. 20% Mannitol was administered at a dose of 0.7 g/kg b. m. with a rate infusion of 10 ml/min. Renal excretory function was evaluated in the first and second postoperative days as well as 1 month and 1 year after renal transplantation. Results: On the 1st postoperative day early diuresis occurred in 16 patients (76%) from group I and in 12 patients (57%) from group II. On the 2nd postoperative day early diuresis occurred in 62% and 48% of patients, respectively. Early diuresis had been followed by a significant decrease in the serum creatinine level. Satisfactory graft function had been found in 95% of patients from group I and in 100% of patients from group II following 30 days after renal transplantation. The one-year graft survival rate was 86% in both groups. Conclusion: Early 20% Mannitol administration significantly increases the chance for early diuresis, but has no influence on short and long-term renal transplantation results.

Keywords: renal transplantation, 20% Mannitol, early diuresis