02 March 1998
Cerebral arterio-venous oxygen content differences (AVDO2) during the operations of intracranial aneurysm with isoflurane anesthesia
Zbigniew Karwacki, Paweł Słoniewski, Janina SuchorzewskaMed Sci Monit 1998; 4(2): CR297-303 :: ID: 502609
Abstract
13 patients subjected to the operational treatment of intracranial aneurysm with isoflurane anaesthesia manifested haemodynamic changes in systemic and cerebral circulation. The evaluation was based upon selected parameters monitored during the operation including expiratory terminal carbon dioxide concentration (ETCO2), core temperature, mean arterial blood pressure (MABP) and cerebral arterio-venous oxygen content difference (AVDO2) - paying special attention to these parameters during the following stages of operation: I - 5 minutes before skin incision, II - 5 minutes after skin incision, III - 5 minutes after meningotomy, IV - 5 minutes after clipping the aneurysm, V - 5 minutes after meningorrhaphy. In the subsequent stages of operation, MABP mean values fluctuated statistically significantly, and there was a negative linear correlation with statistically significant changes of mean AVDO2 values (r=-9107, p<0.05). On the basis of the analysis of mean PaCO2,ETCO2,PjCO2, and core temperature it may be claimed that there is no significant influence of these parameters upon cerebral blood flow and oxygen consumption by cerebral tissue. The results obtained in the present study allow for the conclusion that general complex anaesthesia with low isoflurane concentration does not ensure a full stabilisation of both systemic and cerebral circulation in the most important stages of the operation of intracranial aneurysm. It may also be claimed that the correlation of MABP with AVDO2, changes may indicate the deficiency of the autoregulation mechanism of cerebral circulation in the course of subarachnoid bleeding following the rupture of intracranial aneurysm.
Keywords: cerebral arterio-venous oxygen content, Isoflurane, neuroanaesthesia
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
26 Feb 2024 : Clinical Research
Predictive Value of Combined HbA1c and Neutrophil-to-Lymphocyte Ratio for Diabetic Peripheral Neuropathy in...Med Sci Monit In Press; DOI: 10.12659/MSM.942509
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952