Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

02 March 1998

Lactate dehydrogenase (LDH) and triglycerides (TG) as indicators of the development of pancreatic necrosis in acute experimental pancreatitis (AEP)

Cezary Mirosław

Med Sci Monit 1998; 4(2): HY337-342 :: ID: 502625

Abstract

The aim of the study was to determine the dependence between the beginning of pancreatic necrosis with its acute inflammation and LDH activity in blood and urine, as well as the concentration of TG in blood serum. The study was performed on 107 Wistar type rats. In the experimental group which comprised 68 animals, acute experimental pancreatitis was induced; 24 rats constituted the operational control group and 15 rats constituted the non-operational control group. During the experiment, the level of LDH activity in blood and urine as well as the concentration of TG in blood serum were determined in the 2, 6, 12, 24 and 48 hour after the operation. The pancreas was removed at autopsy for histopathological examination and macroscopic changes in the abdomen were assessed. Single necrotic locations were observed after a period of 12 hours following operation. Evident pancreatic necrosis developed 24 hours after AEP induction. Based on the results of the study, we concluded that the remarkable increase in LDH activity in rat blood serum and urine in AEP, marks the onset of pancreatic necrosis. LDH and TG parameters allow the determination of the beginning of pancreatic necrosis in the course of AP in rats.

Keywords: lactate dehydrogenase, Triglycerides, acute experimental pancreatitis

Add Comment 0 Comments

799 0

Editorial

01 December 2023 : Editorial  

Editorial: Outbreaks of Post-Pandemic Childhood Pneumonia and the Re-Emergence of Endemic Respiratory Infections

Dinah V. Parums

DOI: 10.12659/MSM.943312

Med Sci Monit 2023; 29:e943312

0:00

In Press

04 Dec 2023 : Animal Research  

Effects of Intrathecal Ketamine on Cerebrospinal Fluid Levels of Brain-Derived Neurotrophic Factor and Mech...

Med Sci Monit In Press; DOI:  

01 Dec 2023 : Clinical Research  

Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective St...

Med Sci Monit In Press; DOI:  

30 Nov 2023 : Review article  

Decoding the Neurological Sequelae of General Anesthesia: A Review

Med Sci Monit In Press; DOI:  

30 Nov 2023 : Clinical Research  

Enhanced Pain Relief and Muscle Growth in Individuals with Low Back Instability: The Impact of Blood Flow R...

Med Sci Monit In Press; DOI:  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

0:00

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750