02 March 1998
Lactate dehydrogenase (LDH) and triglycerides (TG) as indicators of the development of pancreatic necrosis in acute experimental pancreatitis (AEP)
Cezary MirosławMed Sci Monit 1998; 4(2): HY337-342 :: ID: 502625
Abstract
The aim of the study was to determine the dependence between the beginning of pancreatic necrosis with its acute inflammation and LDH activity in blood and urine, as well as the concentration of TG in blood serum. The study was performed on 107 Wistar type rats. In the experimental group which comprised 68 animals, acute experimental pancreatitis was induced; 24 rats constituted the operational control group and 15 rats constituted the non-operational control group. During the experiment, the level of LDH activity in blood and urine as well as the concentration of TG in blood serum were determined in the 2, 6, 12, 24 and 48 hour after the operation. The pancreas was removed at autopsy for histopathological examination and macroscopic changes in the abdomen were assessed. Single necrotic locations were observed after a period of 12 hours following operation. Evident pancreatic necrosis developed 24 hours after AEP induction. Based on the results of the study, we concluded that the remarkable increase in LDH activity in rat blood serum and urine in AEP, marks the onset of pancreatic necrosis. LDH and TG parameters allow the determination of the beginning of pancreatic necrosis in the course of AP in rats.
Keywords: lactate dehydrogenase, Triglycerides, acute experimental pancreatitis
799 0
Editorial
01 December 2023 : Editorial
Editorial: Outbreaks of Post-Pandemic Childhood Pneumonia and the Re-Emergence of Endemic Respiratory InfectionsDOI: 10.12659/MSM.943312
Med Sci Monit 2023; 29:e943312
In Press
04 Dec 2023 : Animal Research
Effects of Intrathecal Ketamine on Cerebrospinal Fluid Levels of Brain-Derived Neurotrophic Factor and Mech...Med Sci Monit In Press; DOI:
01 Dec 2023 : Clinical Research
Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective St...Med Sci Monit In Press; DOI:
30 Nov 2023 : Review article
Decoding the Neurological Sequelae of General Anesthesia: A ReviewMed Sci Monit In Press; DOI:
30 Nov 2023 : Clinical Research
Enhanced Pain Relief and Muscle Growth in Individuals with Low Back Instability: The Impact of Blood Flow R...Med Sci Monit In Press; DOI:
Most Viewed Current Articles
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292