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01 January 1998

Class I HLA in patients suffering from tuberculosis - population analysis

Anna Dubaniewicz, Zofia Szczerkowska

Med Sci Monit 1998; 4(1): CR122-126 :: ID: 502841


The aim of the present study was the analysis of the relation between the incidence of tuberculosis and particular class I HLA among patients of hospitals in Gdańsk, Gdynia and Sopot. 115 patients with active tuberculosis were included in the examination of HLA from A, B, C locus. The diagnosis of tuberculosis was confirmed bacteriologically by the detection of Mycobacterium tuberculosis in sputum cultures. The control group consisted of 100 healthy, unrelated adults. The examination of class I antigens was performed according to microlymphocytotoxic NIH test by Terasaka. χ2 test was used for statistical analysis with the confidence level of p<0.05, with the use of Yates' modification. The relative risk was calculated according to Woolf's method. The significantly increased value of the test for HLA-B62(15) (χ2=4.1; p<0.05; RR=2.85) and HLA-Cw5 (χ2=3.86; p<0.05; RR=6.72) was found in tuberculosis on the basis of our results. However we found significantly decreased values of χ2 test among patients suffering from tuberculosis with relative risk RR<1 for antigens: HLA-A2 (χ2&eguals;6.8; p<0.001), -A10 (χ2=72.45; p<0.0001), -A26 (10) (χ=4.03; p<0.05), -A11 (χ2=4.36; p<0.05), -B40 (χ2=25.4; p<0.0001), -B7 (χ2=4.75; p<0.05), -Cw1 (χ2=4.1; p<0.05). On the basis of these results it was concluded that: 1. In the population of patients suffering from tuberculosis, living in the area of North Poland antigens HLA-62(15) and HLA-Cw5 were found significantly more frequently in comparison with control group of healthy people. 2. In the examined group of patients antigens HLA-A2, -A26(10), -A11, -B7, -B40, -Cw1 were found significantly less frequently in comparison with the control group.

Keywords: Tuberculosis, HLA-C, HLA-B, HLA-A

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750