Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 January 1998

Class I HLA in patients suffering from tuberculosis - population analysis

Anna Dubaniewicz, Zofia Szczerkowska

Med Sci Monit 1998; 4(1): CR122-126 :: ID: 502841

Abstract

The aim of the present study was the analysis of the relation between the incidence of tuberculosis and particular class I HLA among patients of hospitals in Gdańsk, Gdynia and Sopot. 115 patients with active tuberculosis were included in the examination of HLA from A, B, C locus. The diagnosis of tuberculosis was confirmed bacteriologically by the detection of Mycobacterium tuberculosis in sputum cultures. The control group consisted of 100 healthy, unrelated adults. The examination of class I antigens was performed according to microlymphocytotoxic NIH test by Terasaka. χ2 test was used for statistical analysis with the confidence level of p<0.05, with the use of Yates' modification. The relative risk was calculated according to Woolf's method. The significantly increased value of the test for HLA-B62(15) (χ2=4.1; p<0.05; RR=2.85) and HLA-Cw5 (χ2=3.86; p<0.05; RR=6.72) was found in tuberculosis on the basis of our results. However we found significantly decreased values of χ2 test among patients suffering from tuberculosis with relative risk RR<1 for antigens: HLA-A2 (χ2&eguals;6.8; p<0.001), -A10 (χ2=72.45; p<0.0001), -A26 (10) (χ=4.03; p<0.05), -A11 (χ2=4.36; p<0.05), -B40 (χ2=25.4; p<0.0001), -B7 (χ2=4.75; p<0.05), -Cw1 (χ2=4.1; p<0.05). On the basis of these results it was concluded that: 1. In the population of patients suffering from tuberculosis, living in the area of North Poland antigens HLA-62(15) and HLA-Cw5 were found significantly more frequently in comparison with control group of healthy people. 2. In the examined group of patients antigens HLA-A2, -A26(10), -A11, -B7, -B40, -Cw1 were found significantly less frequently in comparison with the control group.

Keywords: Tuberculosis, HLA-C, HLA-B, HLA-A

0 Comments

Editorial

01 March 2023 : Editorial  

Editorial: Global Surveillance of Highly Pathogenic Avian Influenza Viruses in Poultry, Wild Birds, and Mammals to Prevent a Human Influenza Pandemic

Dinah V. Parums

DOI: 10.12659/MSM.939968

Med Sci Monit 2023; 29:e939968

SARS-CoV-2/COVID-19

03 March 2023 : Database Analysis  

Reinfections from SARS-CoV-2: A Retrospective Study from the Gyncentrum Genetic Laboratory in Sosnowiec, Po...

Med Sci Monit In Press; DOI: 10.12659/MSM.939452  

09 February 2023 : Clinical Research  

Evaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...

Med Sci Monit 2023; 29:e938892

27 December 2022 : Clinical Research  

Effect of Physiotherapy to Correct Rounded Shoulder Posture in 30 Patients During the COVID-19 Pandemic in ...

Med Sci Monit 2022; 28:e938926

In Press

20 Mar 2023 : Clinical Research  

Management of Unstable C1 Fractures Involving the Lateral Mass: Posterior C1-C2 Screw-Rod Fixation and Fusion

Med Sci Monit In Press; DOI: 10.12659/MSM.938600  

17 Mar 2023 : Clinical Research  

Relationship Between Autonomic Nervous System Activity and Axial Length in Children

Med Sci Monit In Press; DOI: 10.12659/MSM.939451  

15 Mar 2023 : Clinical Research  

Relationship Between Psychological Symptoms and Self-Esteem Levels Before and After Stomach Botox Treatment

Med Sci Monit In Press; DOI: 10.12659/MSM.939618  

15 Mar 2023 : Clinical Research  

Short-Term Patient Outcomes Using the Interlaminar Endoscopic Surgical System Ilessys® Delta System versus ...

Med Sci Monit In Press; DOI: 10.12659/MSM.938477  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750