Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 July 1999

Effect of treatment with methylprednisolone upon concentration of soluble form of IL-2R alpha and soluble forms of adhesive molecules : ICAM-1 and VCAM-1 in serum of patients with multiple sclerosis

Małgorzata Bilińska, Irena Frydecka, Ryszard Podemski

Med Sci Monit 1999; 5(4): CR692-696 :: ID: 503491


The bout of multiple sclerosis implies activation of autoreactive mononuclear cells of peripheral blood and increased expression of adhesive cells on cerebral vessel endothelium. This results in the migration of cells and consequently, in the formation of perivascular infiltrations consisting of lymphocytes and macrophages, as well as the destruction of myelin in the brain and spinal cord. Steroid-therapy reduces clinical symptoms of MS bout, while nuclear magnetic resonance reveals the decrease of demyelinization foci after treatment. The aim of the present work was to evaluate the effect of methylprednisolone therapy upon the activation of immune system and clinical status estimated on EDSS scale. In our study, concentrations of sIL-2R alpha, sICAM-1 and sVCAM-1 were investigated in blood serum with the use of ELISA immunoenzyme assay. The study was performed in the group of 15 patients with the first bout of multiple sclerosis, who received intravenous infusion of methylprednisolone (1g) daily for 5 consecutive days. Neurological examinations as well as the determination of serum levels of cellular differentiation antigens listed above were performed before the start of therapy and 4 weeks after its completion. Control group was formed of 20 healthy persons. In patients with the first bout of the disease, mean serum concentrations of sIL-2R, sICAM-1 and sVCAM-1 were significantly higher when compared with the results obtained in control group. 4 weeks after therapy with methylprednisolone, a considerable improvement of neurological status was observed in patients from the study group. At that time, return to normal serum levels of mean sVCAM-1 concentration and a considerable decrease of mean sICAM-1 concentration were observed, while mean level of sIL-2R alpha did not change in a significant way. The improvement on EDDS scale after treatment correlated with the decrease of sICAM-1 in blood serum. The results of our study suggest that a beneficial clinical effect of steroid therapy in patients with multiple sclerosis may partly result from its inhibiting influence on the expression of adhesive cells, which consequently may lead to reduced migration of activated cells of immune system to central nervous system.

Keywords: Immune System, steroid therapy, Multiple Sclerosis

Add Comment 0 Comments


01 February 2024 : Editorial  

Editorial: Global Health Concerns as Vaccine-Preventable Infections Including SARS-CoV-2 (JN.1), Influenza, Respiratory Syncytial Virus (RSV), and Measles Continue to Rise

Dinah V. Parums

DOI: 10.12659/MSM.943911

Med Sci Monit 2024; 30:e943911


In Press

05 Jan 2024 : Clinical Research  

Effectiveness of Glutamine Oral Care in Reducing Oral Mucositis and Improving Oral Health After Neurosurger...

Med Sci Monit In Press; DOI: 10.12659/MSM.942585  

02 Jan 2024 : Clinical Research  

Urinary Concentration of Renal Biomarkers in Healthy Term Neonates: Gender Differences in GST-pi Excretion

Med Sci Monit In Press; DOI: 10.12659/MSM.942819  

29 Dec 2023 : Clinical Research  

Performance of Subcutaneous Implantable Cardioverter Defibrillator (S-ICD) in Chinese Population with Prima...

Med Sci Monit In Press; DOI: 10.12659/MSM.942747  

08 Jan 2024 : Review article  

Review of Approaches to the Management of Vertical Dental Root Fractures and Tooth Preservation

Med Sci Monit In Press; DOI: 10.12659/MSM.943100  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387


17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799


14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750