Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 July 1999

Evaluation of haemodynamic changes following a single dose of nitrate spray

Janusz Siebert, Jerzy Bellwon, Andrzej Rynkiewicz, Dariusz Ciećwierz

Med Sci Monit 1999; 5(4): PI748-753 :: ID: 504652


It is a documented fact that nitrates have a positive effect on the regression of symptoms of angina pectoris. There are discrepant findings concerning the changes in stroke volume and cardiac index after the administration of a single small dose of isosorbide dinitrate (ISDN) spray. There are still too few data on haemodynamic effects of nitrates of short-term activity in patients on chronic therapy with nitrates of prolonged activity. The aim of the present work was a non-invasive evaluation of the effect of a single dose of ISDN spray (1.25 mg) on haemodynamic indices in patients with stable angina pectoris. The study included 15 men aged 52±8 years, with body mass 82±12 kg, with the symptoms of stable coronary disease confirmed by coronarography. The average of 3 atherosclerotic stenoses exceeding 75% of coronary artery lumen were observed. EF ranged from 38% to 55%. 9 patients displayed arterial hypertension, 7 subjects experienced transmural myocardial infarction. All the patients received nitrates of prolonged activity. In order to stop the attacks of angina pectoris, the patients used nitrates of short-term effect. 15-minute record of changes in preload, stroke volume, cardiac index, heart rate were performed with the use of digital analysis of impedance cardiogram and ECG. In 3rd minute, the patients received 1.25 mg ISDN spray. Arterial blood pressure was measured according to Korotkow method. Changes in systemic vascular resistance were calculated. After the administration of 1.25 mg ISDN spray, preload decreased and reached the level of statistical significance in 9th minute (p<0.05). Stroke volume dropped from 100.04 ml to 90.07 ml in 7th minute after ISDN administration. Cardiac index changed from 3200 ml/m2 to 2950 ml/m2 (p<0.01). Heart rate increased from 62.8±8 / min to 65.8±9 / min (p<0.05). Systolic, diastolic and mean blood pressure decreased (from 131.2±18 mm Hg to 121.5±18 mm Hg; from 81.9±11 mm Hg to 78.2±9 mm Hg; from 98.3±13 mm Hg to 92.6±11 mm Hg, respectively). Systemic vascular resistance changed in 3rd minute after ISDN administration (p<0.05). In five patients, a significant change in stroke volume was observed as early as in 57±14.7 second after the administration of 1.25 mg ISDN spray.

Keywords: HAEMODYNAMICS, impedance cardiography, Nitrates, therapy, Coronary Disease

Add Comment 0 Comments

365 0


01 May 2023 : Editorial  

Editorial: Twenty Years On from Sequencing the Human Genome, Personalized/Precision Oncology Prepares to Meet the Challenges of Checkpoint Inhibitor Therapy

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.940911

Med Sci Monit 2023; 29:e940911

In Press

25 May 2023 : Database Analysis  

COVID-19 Crisis And The Study Of The Incidence Of Alcohol-related Deaths In Poland

Med Sci Monit In Press; DOI: 10.12659/MSM.940904  

25 May 2023 : Review article  

A Review of Preclinical and Clinical Studies in Support of the Role of Non-Steroidal Anti-Inflammatory Drug...

Med Sci Monit In Press; DOI: 10.12659/MSM.940635  

25 May 2023 : Clinical Research  

Periapical Lesions and Missed Canals in Endodontically Treated Teeth: A Cone-Beam Computed Tomographic Stud...

Med Sci Monit In Press; DOI: 10.12659/MSM.940533  

23 May 2023 : Database Analysis  

Association Between Alcohol Consumption and Cardiovascular Risk Based on Data from the Three Generations fo...

Med Sci Monit In Press; DOI: 10.12659/MSM.940327  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750