Logo Medical Science Monitor

Call: +1.631.470.9640
Closed: National Holiday

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

30 April 1999

Role of neurotransmitter aminoacids in generation of cortical epileptic after discharges during ontogenesis

Romana Slamberov‡a

Med Sci Monit 1999; 5(3): BR385-391 :: ID: 504705


Background: Epileptic seizures usually originate as an imbalance between neuronal excitation and inhibition. Two principal ways how to reinstate this balance were tested in our model of myoclonic seizures: a suppression of proconvulsant effects of excitatory amino acids or potentiation of anticonvulsant effects of GABAergic inhibition. Additionally, a combination of both approaches was determined.
Material/Methods: NMDA receptor antagonists (CGP 40116, AP7, dizocilpine) as well as GABA-acting drugs (phenobarbital, clobazam, bretazenil, NNC-711, baclofen and CGP 35348) were tested in three age groups of rats (12, 18 and 25 day old) in the model of neocortical electrically-induced EEG and motor seizures. Three parameters were evaluated: 1. intensity of motor seizures accompanying electrical stimulations, 2. duration of EEG discharges, and 3. intensity of motor seizures accompanying EEG discharges.
Results: All NMDA receptor antagonists exhibited the highest anticonvulsant effect in our model of myoclonic seizures in 25 day old animals. The order of anticonvulsant potency against EEG discharges was: CGP 40116 (competitive antagonist) > AP7 (competitive antagonist) > dizocilpine (noncompetitive antagonist). All drugs facilitating GABAA inhibition (phenobarbital, clobazam, bretazenil and NNC-711) had similar anticonvulsant action in all age groups and were more effective in 25 day old animals. Baclofen as a GABAB agonist displayed only small anticonvulsant activity with weakest anticonvulsant effects in 18 day old rats. GABAB antagonist CGP 35348 had proconvulsant effects in EEG discharges but not in motor manifestations in all age groups. The anticonvulsant effects of the combination of sodium valproate and CGP 40116 were not significantly better than the effects of monotherapy with either drug.
Conclusions: In contrast to other developmental seizure models, we found that both the NMDA receptor antagonists and GABA-acting drugs were more effective against myoclonic seizures in prepubertal rats.

Keywords: electrical stimulation, development, Anticonvulsant drugs, Epileptogenesis, Seizures, sensorimotor region

Add Comment 0 Comments

471 0


01 May 2023 : Editorial  

Editorial: Twenty Years On from Sequencing the Human Genome, Personalized/Precision Oncology Prepares to Meet the Challenges of Checkpoint Inhibitor Therapy

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.940911

Med Sci Monit 2023; 29:e940911

In Press

28 May 2023 : Database Analysis  

Scientometric and Visualized Analysis of Intravoxel Incoherent Motion Magnetic Resonance Imaging: 1988-2021

Med Sci Monit In Press; DOI: 10.12659/MSM.938715  

25 May 2023 : Database Analysis  

The COVID-19 Crisis and the Incidence of Alcohol-Related Deaths in Poland

Med Sci Monit In Press; DOI: 10.12659/MSM.940904  

25 May 2023 : Review article  

A Review of Preclinical and Clinical Studies in Support of the Role of Non-Steroidal Anti-Inflammatory Drug...

Med Sci Monit In Press; DOI: 10.12659/MSM.940635  

25 May 2023 : Clinical Research  

Periapical Lesions and Missed Canals in Endodontically Treated Teeth: A Cone-Beam Computed Tomographic Stud...

Med Sci Monit In Press; DOI: 10.12659/MSM.940533  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750