Logo Medical Science Monitor

Call: +1.631.470.9640
Closed: National Holiday

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

30 April 1999

Quantitative study on lymphocytic infiltrations in metastatic brain tumours

Marzena Harabin-Słowińska, Jerzy Słowiński, Jadwiga Rokicka, Janusz Konecki, Ryszard Mr—ówka

Med Sci Monit 1999; 5(3): BR421-427 :: ID: 504748


The presence of malignant cells within CNS evokes immunological response, manifested morphologically as infiltrations composed of lymphocytes and macrophages. Studying of intensity of these infiltrations may potentially have prognostic value and help to choose patients for future immunotherapy. The aim of the study was to assess quantitatively lymphocytic infiltrations within metastatic tumours of the brain taking into account contribution of T and B cell populations. 48 brain metastases obtained intraoperatively during craniotomy were examined. T-cells and B-cells were identified immunohistochemically on paraffin sections with monoclonal antibodies anti-CD45RO and anti-CD20-Cy, respectively. Afterwards they were counted in 35 randomly selected fields of vision in each specimen. T cells were observed in all 48 brain metastases, B-cells in 39 of them. The mean number of T and B cells seen in a field of a microscope was 3.12 and 0.83. The mean T/B ratio was 7.2. A high positive correlation of intensity of T and B cell infiltrations was found (r=0.45). The lymphocytes were especially abundant in perivascular spaces and in connective tissue tumour stroma. It is concluded that T lymphocytes predominate in lymphocytic infiltrations in brain metastases. A high T/B correlation indicates synchronous activation of cellular and humoral response against the presence of metastatic cancer cells in the brain.

Keywords: tumour stroma, lymphocytic infiltrations, brain metastases, Neoplasms

Add Comment 0 Comments

386 0


01 May 2023 : Editorial  

Editorial: Twenty Years On from Sequencing the Human Genome, Personalized/Precision Oncology Prepares to Meet the Challenges of Checkpoint Inhibitor Therapy

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.940911

Med Sci Monit 2023; 29:e940911

In Press

28 May 2023 : Database Analysis  

Scientometric and Visualized Analysis of Intravoxel Incoherent Motion Magnetic Resonance Imaging: 1988-2021

Med Sci Monit In Press; DOI: 10.12659/MSM.938715  

25 May 2023 : Database Analysis  

The COVID-19 Crisis and the Incidence of Alcohol-Related Deaths in Poland

Med Sci Monit In Press; DOI: 10.12659/MSM.940904  

25 May 2023 : Review article  

A Review of Preclinical and Clinical Studies in Support of the Role of Non-Steroidal Anti-Inflammatory Drug...

Med Sci Monit In Press; DOI: 10.12659/MSM.940635  

25 May 2023 : Clinical Research  

Periapical Lesions and Missed Canals in Endodontically Treated Teeth: A Cone-Beam Computed Tomographic Stud...

Med Sci Monit In Press; DOI: 10.12659/MSM.940533  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750