Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

30 April 1999

Prophylactic administration of intravenous immunoglobulins in the early stage of ischemic stroke

Witold Palasik, Jerzy Popow, Waldemar Lechowicz, Urszula Fiszer, Anna Członkowska

Med Sci Monit 1999; 5(3): CR528-532 :: ID: 504921


The administration of intravenous immunoglobulins (IVIG) in patients with a high risk of infection is considered a possible prophylactic measure in prevention of septic complications. Patients affected by stroke are extremely prone to infections. To determine whether such a treatment might be useful in stroke patients we designed the double-blind, randomized, placebo-controlled study. Seventy-two patients affected by recent (in last five days) acute ischemic stroke (neurological deficit in the Mathew's scale between 30-80 points) were included in the study groups. Patients underwent IVIG therapy (0.1-0.2 g/kg b.w. of Veinoglobuline - Institute Merieux-France on day 1, 3 and 7 of the study) or were given human albumin as a placebo (on the same days). The clinical outcome, septic complication, number of days of fever and use of antibiotics were recorded for 30 days or until patient's death. Three patients in the IVIG treated group and 9 patients in the control group died during the study. In the group receiving IVIG therapy there were no cases of death caused by septic complications. In 5 cases from the control group death was caused by infection. The neurological improvement assessed with the Mathew's scale was greater in the IVIG group compared to the placebo group. Immunological tests showed an enhancement of the immune response after stimulation by PHA and Con A in the group of patients treated with IVIG.

Keywords: infections, Stroke, intravenous gammaglobulin

Add Comment 0 Comments


01 May 2024 : Editorial  

Editorial: First Regulatory Approval for Adoptive Cell Therapy with Autologous Tumor-Infiltrating Lymphocytes (TILs) – Lifileucel (Amtagvi)

Dinah V. Parums

DOI: 10.12659/MSM.944927

Med Sci Monit 2024; 30:e944927

In Press

16 Mar 2024 : Clinical Research  

Diagnostic Efficiency of ACR-TIRADS Score for Differentiating Benign and Malignant Thyroid Nodules of Vario...

Med Sci Monit In Press; DOI: 10.12659/MSM.943228  


08 May 2024 : Clinical Research  

Effect of Individualized PEEP Guided by Driving Pressure on Diaphragm Function in Patients Undergoing Lapar...

Med Sci Monit In Press; DOI: 10.12659/MSM.944022  


21 Mar 2024 : Clinical Research  

Impact of Serum Vitamin D, B6, and B12 and Cognitive Functions on Quality of Life in Peri- and Postmenopaus...

Med Sci Monit In Press; DOI: 10.12659/MSM.943249  

17 Mar 2024 : Clinical Research  

Protective Role of TRPC3 Gene Polymorphism (rs10518289) in Obstructive Sleep Apnea Hypopnea Syndrome Among ...

Med Sci Monit In Press; DOI: 10.12659/MSM.942667  

Most Viewed Current Articles

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799


14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387


01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750