01 March 1999
Effect of sevoflurane on intracranial pressure and systemic circulation in rabbitZbigniew Karwacki, Przemysław Kowiański, Jerzy Dziewiątkowski, Janusz Moryś, Janina Suchorzewska
Med Sci Monit 1999; 5(2): BR181-185 :: ID: 505071
The aim of the study was to compare the effect of gradual and abrupt increase of sevoflurane concentrations on intracranial pressure and systemic circulation in rabbits. The study was performed on 13 adult rabbits divided at random into two groups. In group I (8 rabbits), 2.2 vol%, 4.4 vol% and 6.6 vol% were subsequently administered in three 15 minutes intervals. Animals from group II (5 rabbits) received from the start 6.6 vol% concentration of sevoflurane for 45 minutes. Intracranial pressure (ICP), mean arterial blood pressure (MABP), heart rate (HR), end-expiratory CO2 concentration, temperature in nasopharynx were monitored continuously. Mean ETCO2 values did not differ in a statistically significant way in both groups and they remained at a stable level during observation period. Mean temperature in nasopharynx manifested a slight, though statistically significant decrease when compared to initial value - this was observed in 30th minute in group I, and in 25th minute in group II. Statistically significant increase of ICP observed in 30th minute in group I, was evident in group II as early as in 10th minute. Statistically significant changes when compared with initial values remained such until the end of observation period. There was a positive correlation between changes in ICP values with the changes in end-expiratory concentration of sevoflurane both in group I (p<0.05, r=0.8208) and in group II (p<0.05,r=0.6926). In group I, there was a statistically significant decline of MABP in 30th minute - this tendency was manifested until the end of observation period. Similar course was observed in group II since 5th minute. Changes in MABP values correlated negatively with changes in end-expiratory concentration of sevoflurane in group I (p<0.001, r=-9394) and in group II (p<0.05, r=-0.8299). Statistically significant decrease in heart rate was observed in group I from 25th minute onwards, and in group II - from 5th minute of observation.There was a negative correlation between changes in heart rate and changes in end-expiratory concentration of sevoflurane both in group I (p<0.001, r=-0.9251) and in group II (p<0.05, r=Ð0.7682). The results obtained indicate that the concentrations of sevoflurane below 1 MAC do not have a significant effect on intracranial pressure and systemic circulation. Irrespective of the method of sevoflurane administration, its concentration of 3 MAC results in ICP elevation, which, however, does not exceed upper normal range values. In the case of sevoflurane concentrations higher than 1.5 MAC, the degree of systemic circulatory depression is proportional to the dose administered.
Keywords: rabbit, Heart Rate, mean arterial blood pressure, Intracranial Pressure, sevoflurane
01 March 2023 : EditorialEditorial: Global Surveillance of Highly Pathogenic Avian Influenza Viruses in Poultry, Wild Birds, and Mammals to Prevent a Human Influenza Pandemic
Med Sci Monit 2023; 29:e939968
03 March 2023 : Database AnalysisReinfections from SARS-CoV-2: A Retrospective Study from the Gyncentrum Genetic Laboratory in Sosnowiec, Po...
Med Sci Monit In Press; DOI: 10.12659/MSM.939452
09 February 2023 : Clinical ResearchEvaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...
Med Sci Monit 2023; 29:e938892
19 January 2023 : Clinical ResearchDetermining the Impact of the COVID-19 Pandemic on Dental Care in the Serbian Adult Population: An Online Q...
Med Sci Monit 2023; 29:e939238
27 December 2022 : Clinical ResearchEffect of Physiotherapy to Correct Rounded Shoulder Posture in 30 Patients During the COVID-19 Pandemic in ...
Med Sci Monit 2022; 28:e938926
20 Mar 2023 : Clinical ResearchManagement of Unstable C1 Fractures Involving the Lateral Mass: Posterior C1-C2 Screw-Rod Fixation and Fusion
Med Sci Monit In Press; DOI: 10.12659/MSM.938600
17 Mar 2023 : Clinical ResearchRelationship Between Autonomic Nervous System Activity and Axial Length in Children
Med Sci Monit In Press; DOI: 10.12659/MSM.939451
15 Mar 2023 : Clinical ResearchRelationship Between Psychological Symptoms and Self-Esteem Levels Before and After Stomach Botox Treatment
Med Sci Monit In Press; DOI: 10.12659/MSM.939618
15 Mar 2023 : Clinical ResearchShort-Term Patient Outcomes Using the Interlaminar Endoscopic Surgical System Ilessys® Delta System versus ...
Med Sci Monit In Press; DOI: 10.12659/MSM.938477
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : EditorialEditorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...
Med Sci Monit 2022; 28:e935952