Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 March 1999

Pharmacokinetics of netilmicin in neonates

Jana Malakova, Pavla Pokorna, Zdenek Kokstein, Eva Parizkova, Vladimi’r Palic‹ka, Jiri Vortel, Josef Bukac

Med Sci Monit 1999; 5(2): CR201-207 :: ID: 505080


Netilmicin is an important aminoglycoside antibiotic used in the treatment of most Gram-negative and some Gram-positive infections. The aim of this study was to justify initial dosage guidelines, according to Nelson and to investigate relationships between netilmicin pharmacokinetics and various neonate indices of maturation. The study group comprised 40 neonates aged between 26 to 40 weeks (gestational age). Pharmacokinetic parameters were calculated based on a one-compartment open model by means of Sawchuk and Zaskes method [1,2]. Dosage guidelines according to Nelson, [3] produced high trough netilmicin concentrations above 2 mg/l in 75% of neonates, but peak netilmicin concentrations were within the target range of 5-12 mg/l in 75% of neonates. Results demonstrate the wide interpatient variation in pharmacokinetic parameters. The mean normalized netilmicin clearance was 0.034 l/h/kg and the normalized volume of distribution was 0.506 l/kg. The increase in distribution volume and netilmicin clearance were linear with respect to the gestational and postconceptional age. The correlation between creatinine and netilmicin clearance proved to be signifficant (r=0.64, p<0.001). We recommended netilmicin dosage guidelines in neonates based upon body weight and postconceptional age, since pharmacokinetics correlate with these parameters.

Keywords: neonates, Pharmacokinetics, Netilmicin

Add Comment 0 Comments


01 June 2024 : Editorial  

Editorial: Concerns as Highly Pathogenic Avian Influenza (HPAI) Virus of the H5N1 Subtype is Identified in Dairy Cows and Other Mammals

Dinah V. Parums

DOI: 10.12659/MSM.945315

Med Sci Monit 2024; 30:e945315


In Press

Clinical Research  

Functional Outcomes of Therapeutic Selective Nerve Root Block for Single-Segment Lumbar Spinal Stenosis: A ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943634  

Clinical Research  

Shortening Oral Simethicone-to-Colonoscopy Interval Increases Bowel Preparation Quality

Med Sci Monit In Press; DOI: 10.12659/MSM.943972  

Clinical Research  

Comparative Evaluation of Digital Cephalometric Tracing Applications on Mobile Devices and Manual Tracing

Med Sci Monit In Press; DOI: 10.12659/MSM.944628  

Clinical Research  

Impact of COVID-19-Induced Academic Stress on Insomnia and Suicidal Ideation among Taiwanese Health Trainee...

Med Sci Monit In Press; DOI: 10.12659/MSM.944932  

Most Viewed Current Articles

17 Jan 2024 : Review article   1,801,647

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799


14 Dec 2022 : Clinical Research   1,532,330

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


16 May 2023 : Clinical Research   690,353

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387


01 Jan 2022 : Editorial   50,289

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750