Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 March 1999

Results of palliative cytoreduction chemotherapy in patients with advanced non-small cell lung cancer

Anna Słowik-Gabryelska, Agata Kalicka, Władysław Lasek

Med Sci Monit 1999; 5(2): CR226-232 :: ID: 505091


Large number of patients with advanced non-small cell lung cancer (NSCLC), poor prognosis and controversies on the effectiveness of chemotherapy in advanced cases made us analyse our experiences in that matter. The results of paliative chemotherapy in 110 inoperable, and disqualified from radiotherapy NSCLC patients (stage III B, IV) received 2-6 courses of chemotherapy by Le Chevalier (Vincristin, Cyclophosphamide, Lomustine, Cisplatin) or by Rosell (Mitimycin, Ifosfamide, Cisplatin). Control group consisted of 20 persons with advanced NSCLC, who received paliative radiotherapy. The effectiveness of therapy was established on the basis of survival time, number and quality of remissions and performance status. It was established, that effectiveness of treatment depended upon the tolerance of chemotherapy. The more courses of chemotherapy the more remissions, and longer time of survival. The mean time of survival in symptomatically treated patients was 3 months, whereas in chemotherapy group - 11.8 months. In chemotherapy group, the remissions in 82% of patients were obtained, among them 22% complete tumour regressions. Mean time of survival was: 16.1 months in CR, 11.2 months in PR and 5.1 month in patients without answer to treatment. The obtained remissions allowed to resect the tumour in 12% of patients and to apply radiotherapy in about 50%;. In significant part of patients, after chemotherapy the improvement of performance status was seen. The obtained results of treatment are comparable with others in Europe and the USA.

Keywords: palliative chemotherapy, therapy, lung cancer

Add Comment 0 Comments


01 June 2024 : Editorial  

Editorial: Concerns as Highly Pathogenic Avian Influenza (HPAI) Virus of the H5N1 Subtype is Identified in Dairy Cows and Other Mammals

Dinah V. Parums

DOI: 10.12659/MSM.945315

Med Sci Monit 2024; 30:e945315


In Press

Clinical Research  

Comparative Evaluation of Digital Cephalometric Tracing Applications on Mobile Devices and Manual Tracing

Med Sci Monit In Press; DOI: 10.12659/MSM.944628  


Clinical Research  

Impact of COVID-19-Induced Academic Stress on Insomnia and Suicidal Ideation among Taiwanese Health Trainee...

Med Sci Monit In Press; DOI: 10.12659/MSM.944932  

Review article  

Impact of Workplace Bullying on Nursing Care Quality: A Comprehensive Review

Med Sci Monit In Press; DOI: 10.12659/MSM.944815  

Clinical Research  

Anterior Plate-Supported Cannulated Screw Surgery for Ankle Arthrodesis: Clinical and Radiologic Results in...

Med Sci Monit In Press; DOI: 10.12659/MSM.944452  

Most Viewed Current Articles

17 Jan 2024 : Review article   1,882,405

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799


14 Dec 2022 : Clinical Research   1,538,203

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


16 May 2023 : Clinical Research   690,402

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387


01 Jan 2022 : Editorial   50,329

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750