Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 March 1999

Non-neoplastic lymphocyte subsets in patients with B-cell chronic lymphocytic leukemia (B-CLL)

Urszula Podstawka, Joanna Kopeć-Szlężak, Grażyna Pałynyczko, Ewa Mendek-Czajkowska, Lech Konopka

Med Sci Monit 1999; 5(2): CR239-245 :: ID: 505095


Since the early 1980s we observed populations of T lymphocytes and NK cells of B-cell chronic lymphocytic leukemia (B-CLL)patients, reveal changes as compared with T and NK cells of healthy donors. The aim of this study was to determine relations between T-lymphocyte subpopulations and NK-cell subsets in patients with B-CLL in various stages of the disease.Peripheral blood cells of B-CLL patients had been analysed by means of flow cytometry and monoclonal antibodies. Lymphocyte surface markers had been evaluated by means of direct immunofluorescence. We evaluated the absolute number of each lymphocyte subset. Study results revealed that there was a significant increase in the number of T- and NK-cell populations that correlates with the progression of the disease. Following effective therapy of B-CLL Rai stage III/IV patients (blood lymphocyte count <30x109/l) there was a considerable decrease of  T CD3+ and T CD8+ lymphocytes (to control values) and a significant decrease of T CD4+ and NK cells (below minimal control values). The number of T and NK cell subpopulations was not constant and this instability might have been the cause of immune response impairment observed in B-CLL patients. T lymphocytes and NK cells showed normal expression of an adhesion LFA-1 molecule.

Keywords: Rai stage, B-cell chronic lymphocytic leukemia, NK cells, T cell subpopulations



01 March 2023 : Editorial  

Editorial: Global Surveillance of Highly Pathogenic Avian Influenza Viruses in Poultry, Wild Birds, and Mammals to Prevent a Human Influenza Pandemic

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.939968

Med Sci Monit 2023; 29:e939968


In Press

27 Mar 2023 : Database Analysis  

Relationship Between Physical Activity and Adult Asthma Control Using NHANES 2011-2020 Data

Med Sci Monit In Press; DOI: 10.12659/MSM.939350  

27 Mar 2023 : Clinical Research  

Evaluation of the One-Hour ¹³C-Propionate Breath Test in 49 Patients from a Single Center in Japan to Detec...

Med Sci Monit In Press; DOI: 10.12659/MSM.940238  

24 Mar 2023 : Database Analysis  

Causes of Death Following Gastric Cancer Diagnosis: A Population-Based Analysis

Med Sci Monit In Press; DOI: 10.12659/MSM.939848  

22 Mar 2023 : Special report  

One Year On: Poland’s Public Health Initiatives and National Response to Millions of Refugees from Ukraine

Med Sci Monit In Press; DOI: 10.12659/MSM.940223  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750