Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 March 1999

Diagnostic assessment of optimized-qualiative and quantitative 99mTc-MIBI planar perfusion myocardial scintigrams analysis in the detection of coronary artery diseases

Jacek Kuśmierek, Anna Płachcińska, Małgorzata Bieńkiewicz, Maciej Kośmider

Med Sci Monit 1999; 5(2): MT324-332 :: ID: 505147

Abstract

The aim of this study was to verify the adequacy of the diagnostic criterion applied in previously described quantitative planar scintigraphic methods of coronary artery disease detection, as well as to develop, optimize and determine the diagnostic value of the scintigraphic method in the detection of this disease based on qualitative and quantitative heart scintigrams. The study group comprised 304 patients with a suspected coronary heart disease, with no history of a previous myocardial infarction. Group I comprised 197 patients (65 females and 132 males), divided into two independent subgroups, IA and IB, comprising 90 and 107 patients, respectively. In group I patients, scintigraphic findings were verified by means of coronary angiography. Group II comprised 107 patients (67 females and 40 males) with a low (<10) initial probability of coronary disease, who were not subject to coronary angiography. On the basis of examinations performed in subgroup IA, we optimized the qualitative and quantitative criteria of myocardial perfusion evaluation. Adequacy of selected criteria was analysed on the basis of findings obtained from subgroup IB, comparing sensitivity, specificity and accuracy indices obtained from both groups. During qualitative evaluation they amounted respectively to 89.74 and 80% in IA and 86.72 and 79% in IB (no statistically significant differences), while during quantitative evaluation they equalled 86.87 and 87% in IA and 84.84 and 84% in IB (no statistically significant differences), respectively. Comparison of qualitative and quantitative results indicated a significantly higher (p<0.05) specificity of the quantitative method in both group I subgroups. During the second stage the previously optimized diagnostic criteria were applied in order to compare basic diagnostic efficacy indices for the qualitative, quantitative and combined methods, separately in the female (n=65) and male (n=132) groups. The quantitative evaluation of scintigrams in women and combined in men yielded optimal results in the diagnostics of coronary artery diseases. Sensitivity, specificity and accuracy in women amounted to 81.84 and 83%, while in men 95.82 and 89%, respectively. A significantly higher (p<0.05) sensitivity was noted in men. Normality rate values obtained on the basis of group II patient investigations were high - 91% in females and 93% in males. Methods of scintigrams evaluation different for each sex, allow to obtain optimized, high diagnostic efficacy indicesof planar perfusion scintigraphy in the diagnostics of coronary artery diseases.

Keywords: myocardial perfusion scintigraphy, technetium-99mTc methoxyisobutylisonitrile, planar scintigraphy, Coronary Artery Disease, optimization

0 Comments

Editorial

01 March 2023 : Editorial  

Editorial: Global Surveillance of Highly Pathogenic Avian Influenza Viruses in Poultry, Wild Birds, and Mammals to Prevent a Human Influenza Pandemic

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.939968

Med Sci Monit 2023; 29:e939968

SARS-CoV-2/COVID-19

In Press

27 Mar 2023 : Database Analysis  

Relationship Between Physical Activity and Adult Asthma Control Using NHANES 2011-2020 Data

Med Sci Monit In Press; DOI: 10.12659/MSM.939350  

27 Mar 2023 : Clinical Research  

Evaluation of the One-Hour ¹³C-Propionate Breath Test in 49 Patients from a Single Center in Japan to Detec...

Med Sci Monit In Press; DOI: 10.12659/MSM.940238  

24 Mar 2023 : Database Analysis  

Causes of Death Following Gastric Cancer Diagnosis: A Population-Based Analysis

Med Sci Monit In Press; DOI: 10.12659/MSM.939848  

22 Mar 2023 : Special report  

One Year On: Poland’s Public Health Initiatives and National Response to Millions of Refugees from Ukraine

Med Sci Monit In Press; DOI: 10.12659/MSM.940223  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750