Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 March 1999

Diagnostic assessment of optimized-qualiative and quantitative 99mTc-MIBI planar perfusion myocardial scintigrams analysis in the detection of coronary artery diseases

Jacek Kuśmierek, Anna Płachcińska, Małgorzata Bieńkiewicz, Maciej Kośmider

Med Sci Monit 1999; 5(2): MT324-332 :: ID: 505147

Abstract

The aim of this study was to verify the adequacy of the diagnostic criterion applied in previously described quantitative planar scintigraphic methods of coronary artery disease detection, as well as to develop, optimize and determine the diagnostic value of the scintigraphic method in the detection of this disease based on qualitative and quantitative heart scintigrams. The study group comprised 304 patients with a suspected coronary heart disease, with no history of a previous myocardial infarction. Group I comprised 197 patients (65 females and 132 males), divided into two independent subgroups, IA and IB, comprising 90 and 107 patients, respectively. In group I patients, scintigraphic findings were verified by means of coronary angiography. Group II comprised 107 patients (67 females and 40 males) with a low (<10) initial probability of coronary disease, who were not subject to coronary angiography. On the basis of examinations performed in subgroup IA, we optimized the qualitative and quantitative criteria of myocardial perfusion evaluation. Adequacy of selected criteria was analysed on the basis of findings obtained from subgroup IB, comparing sensitivity, specificity and accuracy indices obtained from both groups. During qualitative evaluation they amounted respectively to 89.74 and 80% in IA and 86.72 and 79% in IB (no statistically significant differences), while during quantitative evaluation they equalled 86.87 and 87% in IA and 84.84 and 84% in IB (no statistically significant differences), respectively. Comparison of qualitative and quantitative results indicated a significantly higher (p<0.05) specificity of the quantitative method in both group I subgroups. During the second stage the previously optimized diagnostic criteria were applied in order to compare basic diagnostic efficacy indices for the qualitative, quantitative and combined methods, separately in the female (n=65) and male (n=132) groups. The quantitative evaluation of scintigrams in women and combined in men yielded optimal results in the diagnostics of coronary artery diseases. Sensitivity, specificity and accuracy in women amounted to 81.84 and 83%, while in men 95.82 and 89%, respectively. A significantly higher (p<0.05) sensitivity was noted in men. Normality rate values obtained on the basis of group II patient investigations were high - 91% in females and 93% in males. Methods of scintigrams evaluation different for each sex, allow to obtain optimized, high diagnostic efficacy indicesof planar perfusion scintigraphy in the diagnostics of coronary artery diseases.

Keywords: myocardial perfusion scintigraphy, technetium-99mTc methoxyisobutylisonitrile, planar scintigraphy, Coronary Artery Disease, optimization

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

26 Feb 2024 : Clinical Research  

Predictive Value of Combined HbA1c and Neutrophil-to-Lymphocyte Ratio for Diabetic Peripheral Neuropathy in...

Med Sci Monit In Press; DOI: 10.12659/MSM.942509  

Most Viewed Current Articles

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750